# Participatory Research to Advance Colon Cancer Prevention

> **NIH NIH U01** · KAISER FOUNDATION RESEARCH INSTITUTE · 2020 · $125,000

## Abstract

PROJECT SUMMARY/ABSTRACT:
Colorectal cancer is the third-leading cause of cancer death in the United States. This is troubling given that
screening rates are marked by a pronounced disparity, with Latinos who have been in the United States for
fewer than 10 years and the uninsured having the lowest rates. These individuals generally receive care at
one of over 1,200 federally qualified health centers (FQHCs) that serve over 21 million persons nationwide.
While colorectal cancer screening rates among FQHC patients are a cause for great concern, studies have
demonstrated success for improving screening rates. Programs that mail fecal immunochemical testing (FIT)
kits with pictograph instructions to eligible patients report higher screening rates. While new technologies,
such as automated phone calls and text messages, have been explored to remind patients to complete
screening, little is known about their effectiveness in diverse populations. Moreover, such programs often
adopt a one-size fits all approach and their effectiveness has not been tested among subgroups least likely
to be screened. To address these issues, we will work with the advisory board assembled for our successful
STOP CRC project and additional community stakeholders to adapt and spread a direct-mail FIT and
reminder program (PROMPT) in two phases. In Phase I, we will design and evaluate a randomized
controlled trial to test systems-based, automated and non-automated strategies to increase colorectal cancer
screening in an FQHC with diverse patient populations. In Phase II, we will assess the spread of the program
to 11 clinics (estimated age-eligible patient population ~ 22,000). The proposed study's design and
evaluation will be guided by the RE-AIM framework using intervention mapping and will involve low-income
and ethnically diverse patients who are served by Yakima Valley Farmworkers Clinic. PROMPT will be the
first trial to sequentially test the effectiveness of reminders to a direct-mail colorectal cancer screening
program, then spread the selected best practice to additional clinics within the FQHC network. PROMPT will
apply novel and locally develop strategies to engage stakeholders in adapting the intervetion, defining the
intervention components, and selecting a best practice for spread. If the trial succeeds, it will have broad-
scale implementation potential for a similar program to decrease cancer screening disparities.

## Key facts

- **NIH application ID:** 10018533
- **Project number:** 3U01MD010665-05S1
- **Recipient organization:** KAISER FOUNDATION RESEARCH INSTITUTE
- **Principal Investigator:** Gloria D. Coronado
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $125,000
- **Award type:** 3
- **Project period:** 2016-09-27 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10018533

## Citation

> US National Institutes of Health, RePORTER application 10018533, Participatory Research to Advance Colon Cancer Prevention (3U01MD010665-05S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10018533. Licensed CC0.

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