# Core C: Cell Processing and Immune Monitoring Core

> **NIH NIH P01** · STANFORD UNIVERSITY · 2020 · $537,125

## Abstract

Core C (Cell Processing and Immune Monitoring Core): Project Summary/Abstract
The Cell Processing and Immune Monitoring Core (Core C) will support each of the projects in this proposal by
leveraging existing infrastructure at Stanford University and assisting project investigators in the standardized
use of these resources. Core C provides technical expertise and regulatory support in the preparation of cellular
products for clinical trials including product manipulation and characterization, quality management, and process
documentation. This support will be provided by the Stanford Health Care Cellular Therapy Facility (CTF). By
offsetting development and manufacturing costs, and providing support to a dedicated cellular pharmacist, Core
C provides processing for cell-based therapeutics compliant with both current Good Tissue Practices (cGTP)
and current Good Manufacturing Practices (cGMP). An important function of Core C is to facilitate interaction
between the clinical and research arms of the program by assisting with the translational development of cell-
based therapies from pre-clinical models. Core C facilitates tissue banking and manages sample distribution to
investigators. Through a collaborative arrangement between the CTF and the Stanford Spectrum Biobank, Core
C will support a project-based tissue bank including collection of material from donor grafts, cell products and
pre- and post-transplant blood specimens for long term storage and use by project teams. Core C provides
standardized immune monitoring of the T cell receptor repertoire and facilitates use of other specialized immune
assays through existing institutional shared core facilities. Building on our past Core C optimization of a platform
for measuring TCR Vb CDR3 repertoire, we will provide standardized TCR sequencing to each project, with a
goal of having the donor graft, experimental cell product, and post-transplant samples evaluated in the same
manner for each project. We will also assist each project in accessing and using the resources for immune
monitoring available through the Human Immune Monitoring Core (HIMC) and genomics service centers. In
summary, this Core serves to help integrate the PPG into the large infrastructure established at Stanford for
conducting and scientifically monitoring cellular therapy clinical trials, thus avoiding the unnecessary duplication
of resources and enhancing efficiency.

## Key facts

- **NIH application ID:** 10018831
- **Project number:** 5P01CA049605-30
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** EVERETT MEYER
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $537,125
- **Award type:** 5
- **Project period:** 1997-05-01 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10018831

## Citation

> US National Institutes of Health, RePORTER application 10018831, Core C: Cell Processing and Immune Monitoring Core (5P01CA049605-30). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10018831. Licensed CC0.

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