# Development and Validation of a Collaborative Web/Cloud-Based Dosimetry System for Radiopharmaceutical Therapy.

> **NIH NIH R44** · RADIOPHARMACEUTICAL IMAGING AND DOSIMETRY, LLC · 2020 · $162,019

## Abstract

Project Summary
 Radiopharmaceutical therapy (RPT) – the use of targeted radionuclides to deliver radiation specifically to
cancer cells and their microenvironment – is a fundamentally different approach to cancer therapy that is growing,
with a substantial number of large and small pharmaceuticals companies developing products in this area and
radionuclide producers making substantial investments in scaling up production. This is especially true in the
area of alpha emitters. The dosimetric evaluation of therapeutic radiopharmaceuticals is a key requirement for
regulatory approval and optimal administration of RPTs, especially in combination with external beam radiation
therapy. This project will provide a cloud-based dosimetry software service, delivered through a web-browser,
that includes the full complement of methods needed for dosimetry in the context of obtaining regulatory approval
of RPTs and, ultimately, for optimal clinical delivery. Providing this in a cloud-based system will enable a variety
of models for selling the service that do not require a large up-front capital investment for clinics or
radiopharmaceutical developers. It also will provide access to expert advice, customization, and dosimetry
services, and allow for collaboration between developers, dosimetry experts, and clinical sites. To accomplish
the goal of developing this cloud-based web-browser-delivered RPT dosimetry software service, we propose the
following specific aims: (1) Design, develop and implement a web/cloud-based integrated software system for
treatment planning of RPT therapy; (2) design and implement a full server-side framework for subscription,
authentication, and granting collaborative privileges for the various processes and data in the dosimetry pipeline;
(3) optimize and adapt the four most computationally intensive processes for a multi-processor cloud-based
compute environment; (4) apply and evaluate the toolchain developed in aims 1-3 to phantom, simulated and
existing patient data. Successful completion of this project will produce a cloud-based software system delivered
to the user via a web browser that provides an integrated, streamlined, robust, state-of-the-art system for RPT
treatment planning. This system would enable a collaborative approach to multi-center clinical trials and
eventually to clinical delivery of optimally dosed RPT.

## Key facts

- **NIH application ID:** 10019481
- **Project number:** 5R44CA213782-03
- **Recipient organization:** RADIOPHARMACEUTICAL IMAGING AND DOSIMETRY, LLC
- **Principal Investigator:** ERIC C. FREY
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $162,019
- **Award type:** 5
- **Project period:** 2018-09-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10019481

## Citation

> US National Institutes of Health, RePORTER application 10019481, Development and Validation of a Collaborative Web/Cloud-Based Dosimetry System for Radiopharmaceutical Therapy. (5R44CA213782-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10019481. Licensed CC0.

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