# Development of a novel ophthalmic probe for cerebral amyloid angiopathy

> **NIH NIH R44** · AMYDIS DIAGNOSTICS, INC. · 2020 · $1,049,456

## Abstract

PROJECT SUMMARY
 Cerebral amyloid angiopathy (CAA) is a common neuropathological finding among older
adults and is characterized by amyloid beta (Aβ) deposits in blood vessel walls of the brain. CAA
is a major cause of spontaneous intracerebral hemorrhage and an important contributor to age
related cognitive decline. Diagnosis is often missed by physicians as the presenting symptoms
are similar to a stroke and can be further complicated as CAA is found in over 80% of Alzheimer’s
disease patients. Standard diagnosis of probable CAA involves expensive imaging techniques
and an invasive brain biopsy. The only definitive way to diagnose CAA is through post-mortem
analysis. An ante-mortem diagnostic is needed that can reliably identify CAA at the early,
asymptomatic stages, enabling a correct diagnosis to avoid medications contraindicated in the
disease. Furthermore, a useful and affordable outcome marker is needed for clinical trials focused
on therapies for CAA that could stop or reverse progression of the disease. Amydis aims to
address these unmet needs by identifying A in the eye, as a window to the brain, for early
detection of CAA.
 Several amyloid forming peptides can lead to CAA, among them, amyloid beta (1-40), Aβ40,
is by far the most prevalent form. Amydis’ probes have demonstrated significant fluorescence
enhancement in vitro with synthetically aggregated Aβ40, the ability to detect retinal amyloid
deposits in vivo in transgenic mouse models, and detection of amyloid deposits ex vivo with
human brain tissue from CAA patients. We have selected our lead clinical candidate, AMDX-
2011P, based on properties amenable for commercial development. With this proposal we aim to
1) develop a chemical synthesis and formulation of AMDX-2011P in preparation for clinical trials,
2) complete preclinical studies to assess the metabolism, pharmacokinetics and toxicity of AMDX-
2011P and 3) complete investigational new drug (IND) enabling studies to file an IND with the
FDA. Completion of these aims will advance the development of our in vivo ocular diagnostic test
into human clinical trials, getting us one step closer to our mission of providing an ante-mortem,
simple and affordable CAA diagnostic.

## Key facts

- **NIH application ID:** 10020887
- **Project number:** 5R44AG058350-03
- **Recipient organization:** AMYDIS DIAGNOSTICS, INC.
- **Principal Investigator:** Stella Sarraf
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,049,456
- **Award type:** 5
- **Project period:** 2017-09-15 → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10020887

## Citation

> US National Institutes of Health, RePORTER application 10020887, Development of a novel ophthalmic probe for cerebral amyloid angiopathy (5R44AG058350-03). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10020887. Licensed CC0.

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