# Development and validation of novel models for cerebral small vessel disease and vascular cognitive impairment

> **NIH NIH R61** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $560,704

## Abstract

PROJECT SUMMARY
Vascular cognitive impairment and dementia (VCID) is any level of cognitive alteration that is attributable to
cerebrovascular pathologies. VCID is second only to Alzheimer's disease as a cause of dementia and
accounts for ~15-30% of all dementia cases. Cerebral small vessel diseases (cSVDs) are group of pathologies
afflicting the microcirculation of the brain that collectively account for up to 20% of all strokes and is the most
common pathology underlying VCID. The impact of cSVD and VCID is expected to increase rapidly as the
population of the US and other countries ages. Importantly, the pathogeneses of cSVDs are incompletely
understood which represents a major barrier in developing strategies for prevention and treatment. Research
described in this proposal will develop and validate five novel mouse models of cSVD based on genes and
mutations that are demonstrated to contribute to human disease. We have assembled an interdisciplinary team
of experts that will integrate unique genetic resources, vascular pressure myography, patch-clamp
electrophysiology, calcium imaging, specialized magnetic resonance imaging modalities and learning and
memory behavior assays to develop and characterize multiple novel genetic models of cSVD using genes that
contribute to disease in humans. Our long-term objective is to develop and employ genetic models that
faithfully recapitulate important hallmarks of human cSVD and VCID.

## Key facts

- **NIH application ID:** 10021037
- **Project number:** 5R61NS115132-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Myriam Marianne Chaumeil
- **Activity code:** R61 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $560,704
- **Award type:** 5
- **Project period:** 2019-09-18 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10021037

## Citation

> US National Institutes of Health, RePORTER application 10021037, Development and validation of novel models for cerebral small vessel disease and vascular cognitive impairment (5R61NS115132-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10021037. Licensed CC0.

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