# Data Core

> **NIH NIH U54** · BOSTON UNIVERSITY MEDICAL CAMPUS · 2020 · $343,810

## Abstract

The proposed U54 application will examine the association of repetitive head impacts (RHI) and traumatic brain
injury (TBI) with Alzheimer's disease (AD) and related dementias (ADRD), chronic traumatic encephalopathy
(CTE), and other neuropathologies, and their resulting clinical syndromes. The primary mission of the Data
Coordinating Core (DCC) is to provide leadership and expertise in all phases of data management and statistical
analyses, from development of project infrastructure to publication of results. This collaborative assistance
encompasses data sharing, development of the analytic plan, database design, implementation of data collection
and quality control procedures, technical support, creation of analytic datasets, statistical analyses, and
manuscript preparation. Our overall aim is to provide procedural consistency and efficiency of study-wide
systems, ultimately producing the highest quality data and analysis for use by study researchers and affiliates.
DCC will harmonize data from the 8 novel brain banks: 6 at Boston University (BU): VA-BU-CLF or UNITE,
Chronic Effects of Neurotrauma Consortium (CENC), Alzheimer's Disease Center (BUADC), VA Amyotrophic
Lateral Sclerosis (ALS), VA Post-Traumatic Stress Disorder (PTSD) and Framingham Heart Study (FHS) brain
banks and 2 at ISMMS : Late Effects of TBI (LETBI) and AD Research Center (ADRC). The main objectives of
the DCC are to maintain an integrated, user-friendly data management system and to implement procedures to
ensure the highest quality data, security, and integrity; to provide active and integral collaboration in
methodological design and statistical analysis to all supported project investigators; and to provide systems and
support for resource sharing across all study sites and collaborators. To accomplish these goals, we aim 1) to
provide centralized data infrastructure using integrated, user-friendly systems for sharing of information, data,
and analysis tools. 2) to provide centralized data management using integrated, user-friendly systems for sharing
of information, data, and analysis tools; 3) to disseminate integrated datasets to accelerate the impact of the
study's research objectives; 4) to provide high-level biostatistical expertise for all study's projects.

## Key facts

- **NIH application ID:** 10021465
- **Project number:** 5U54NS115266-02
- **Recipient organization:** BOSTON UNIVERSITY MEDICAL CAMPUS
- **Principal Investigator:** Yorghos Tripodis
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $343,810
- **Award type:** 5
- **Project period:** 2019-09-30 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10021465

## Citation

> US National Institutes of Health, RePORTER application 10021465, Data Core (5U54NS115266-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10021465. Licensed CC0.

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