# Medication Adherence After Stroke

> **NIH NIH R03** · FLORIDA INTERNATIONAL UNIVERSITY · 2021 · $11,538

## Abstract

PROJECT SUMMARY
As many as half of stroke survivors fail to take their medications as prescribed resulting in unnecessary
hospitalizations, morbidity, and mortality. While there is extensive literature on medication adherence in chronic
conditions, like hypertension, little is known about medication adherence in stroke survivors. Subsequently,
current interventions to help stroke survivors improve medication adherence are not very effective. The
overarching goal of the Medication Adherence after Stroke (MAST) project is to better understand medication
adherence in stroke survivors. Findings from this study will facilitate the development of an evidence-based
theory-driven medication adherence intervention, which is anticipated to improve stroke survivors’ health and
well-being. Specifically, this exploratory study will describe medication adherence after stroke through two key
comparisons. First, we will quantitatively and qualitatively compare the factors affecting medication adherence
in 64 stroke survivors with 64 people with hypertension without disability (specific aim 1). People with
hypertension are an optimal comparative sample, as hypertension is a leading risk factor for stroke and both
populations are prescribed similar antihypertensive medications. This comparison will help us translate the
sizable literature on medication adherence from people with hypertension to create a more effective
intervention for stroke survivors. Second, we will compare the adequacy of two theoretical models in predicting
64 stroke survivors’ medication adherence (specific aim 2). The Health Belief Model is a popular theoretical
model informing medication adherence interventions for people with hypertension and other chronic conditions.
The Person-Environment-Occupation Model is an novel theoretical model informing stroke rehabilitation. This
comparison will identify the best theoretical model on which to base future medication adherence intervention
work for stroke survivors. In this study, participants will be asked to describe their demographics, medication
regimen, stroke knowledge, beliefs about medications, and medication adherence. They will participate in an
interview about taking medications and be rated on their ability to correctly complete a standardized medication
task. Then, using an electronic monitoring system, participants will track their medication adherence for 30
days. The MAST study includes an innovative combination of research approaches from the medication
adherence and stroke literatures to support a successful study.

## Key facts

- **NIH application ID:** 10022148
- **Project number:** 5R03HD097729-02
- **Recipient organization:** FLORIDA INTERNATIONAL UNIVERSITY
- **Principal Investigator:** Jaclyn K Schwartz
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $11,538
- **Award type:** 5
- **Project period:** 2019-09-20 → 2021-11-19

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10022148

## Citation

> US National Institutes of Health, RePORTER application 10022148, Medication Adherence After Stroke (5R03HD097729-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10022148. Licensed CC0.

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