# Structural Insights into TRPV Channel Gating

> **NIH NIH R01** · UNIVERSITY OF PENNSYLVANIA · 2020 · $445,964

## Abstract

PROJECT SUMMARY/ABSTRACT
Transient receptor potential (TRP) channels play significant roles in human physiology and facilitate essential
ions' (Na+, Ca2+) permeation through the plasma membrane. The focus of this proposal is on the transient
receptor potential vanilloid
2
(TRPV2), which plays an essential role in cardiac function and immunity, and has
been placed on the list of important anti-tumor drug targets. Nevertheless, it remains the least studied TRPV
channel at the cellular and molecular levels. We propose to use the combination of cryo-EM,
electrophysiological analysis, site-directed mutagenesis, and computational methods to establish a detailed
structural understanding of the mechanisms of TRPV2 channel gating. In this current proposal we will focus on
understanding TRPV2 regulation by phosphoinositides, determine the mechanism of TRPV2 gating by diverse
ligands and dissect the molecular mechanism of TRPV2 interaction with cytoskeleton. Information obtained
upon completion of these studies will be potentially used for future design of TRPV2 specific therapeutics.

## Key facts

- **NIH application ID:** 10022499
- **Project number:** 5R01GM103899-08
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Vera Moiseenkova-Bell
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $445,964
- **Award type:** 5
- **Project period:** 2013-08-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10022499

## Citation

> US National Institutes of Health, RePORTER application 10022499, Structural Insights into TRPV Channel Gating (5R01GM103899-08). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10022499. Licensed CC0.

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