# NOTCH-PAX9 signaling in alcohol-induced esophageal injury

> **NIH NIH R21** · NORTH CAROLINA CENTRAL UNIVERSITY · 2020 · $212,750

## Abstract

PROJECT SUMMARY
This R21 proposal is designed to use cell and mouse models to understand the role of NOTCH-PAX9 signaling
pathway in alcohol-induced esophageal injury. We hypothesize that ethanol suppresses esophageal squamous
cell differentiation through inhibition of the NOTCH-PAX9 signaling. We plan to test our hypothesis with two
specific aims: (1) To determine whether ethanol suppresses esophageal squamous epithelial cell differentiation
through inhibition of the NOTCH-PAX9 signaling. (2) To investigate whether NOTCH activation counteracts
alcohol-induced esophageal injury. These studies are aimed to elucidate the role of NOTCH-PAX9 signaling in
alcohol-induced esophageal injury. If proved true, it will lay down a solid mechanistic foundation to further
study NOTCH activation as a novel mechanism-based preventive measure against alcohol-induced
esophageal injury.

## Key facts

- **NIH application ID:** 10023247
- **Project number:** 5R21AA028047-02
- **Recipient organization:** NORTH CAROLINA CENTRAL UNIVERSITY
- **Principal Investigator:** XIAOXIN Luke CHEN
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $212,750
- **Award type:** 5
- **Project period:** 2019-09-25 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10023247

## Citation

> US National Institutes of Health, RePORTER application 10023247, NOTCH-PAX9 signaling in alcohol-induced esophageal injury (5R21AA028047-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10023247. Licensed CC0.

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