# In Vitro Models and Cell Culture Core

> **NIH NIH P01** · UNIVERSITY OF IOWA · 2020 · $185,400

## Abstract

PROJECT SUMMARY/ABSTRACT - In Vitro Models Cell Culture Core (CORE B )
The In Vitro Models and Cell Culture Core was established to provide well-differentiated epithelial models for
studies on the pathophysiology of cystic fibrosis (CF) and for molecular and gene therapy experiments. The In
Vitro Models and Cell Culture Core mission is to advance CF research to impact the health of people with CF.
The Core achieves that mission by providing relevant models and technical expertise to investigators, developing
new models and approaches, training investigators, and attracting new investigators to CF research and aiding
their development. The goals of the In Vitro Models and Cell Culture Core are to collect, process and biobank
tissue and airway epithelia from human, pig, and ferret. The Core also maintains a biobank of human non-CF
and CF epithelia, including CF epithelia with rare mutations. The Core will also characterize models and native
epithelia in collaboration with other Cores and investigators and will perform bioelectric analyses,
morphological evaluation, gene expression profiles, and flow cytometry. Finally, the Core will teach
investigators at the University of Iowa and other institutions how to successfully implement the methods for in
vitro model systems.

## Key facts

- **NIH application ID:** 10024663
- **Project number:** 1P01HL152960-01
- **Recipient organization:** UNIVERSITY OF IOWA
- **Principal Investigator:** Joseph Zabner
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $185,400
- **Award type:** 1
- **Project period:** 2020-09-01 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10024663

## Citation

> US National Institutes of Health, RePORTER application 10024663, In Vitro Models and Cell Culture Core (1P01HL152960-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10024663. Licensed CC0.

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