# Advanced Imaging and Dosimetry Core

> **NIH NIH P01** · UNIVERSITY OF WISCONSIN-MADISON · 2020 · $293,681

## Abstract

PROJECT SUMMARY
The Advanced Imaging and Dosimetry Core (AIDC) provides the infrastructure, resources, and expertise
required to facilitate quantitative multiscale imaging and dosimetry calculations, which are required to optimally
synergize the combination of molecular targeted radionuclide therapy (TRT) and immunotherapy (ImmRx). The
AIDC is a centralized dosimetry service that will ensure consistent scientific rigor and dosimetry reporting across
each of the Projects of this PO1 proposal, entitled “Molecular targeted radionuclide therapy for tumor
immunomodulation and enhancing immunotherapy response”. Furthermore, the significance of centralizing this
process for each Project is the tremendous gain in efficiency that are achieved, ultimately saving individual
investigators time and effort. Additionally, the AIDC will expand the leadership and operation of the Small Animal
Imaging and Radiotherapy Facility (SAIRF) by offering support in all stages of the imaging and TRT dosimetry
process, including calibration, experimental design, image acquisition optimization, pharmacokinetic profiling
and modeling, micro-and macroscopic 3D dose calculations, and treatment response assessment. The
AIDC will emphasize quality assurance and quality control in all aspects of the imaging and dosimetry process
so that results are validated for application to the FDA. The AIDC will collaborate closely with the Radionuclide
Production and Radiochemistry Core (RPRC) for dose calibration and traceability of the radiopharmaceuticals;
and, the AIDC will collaborate with the Biostatistics and Bioinformatics Core (BBC) to help interpret imaging and
dosimetry findings to validate response assessment. Lastly, the AIDC will help investigators disseminate their
findings to the scientific community through publications and conference presentations. Renowned experts in
the field of TRT dosimetry, Professor Bryan Bednarz and Joseph Grudzinski, will lead administrative and
technical efforts, respectively.

## Key facts

- **NIH application ID:** 10024892
- **Project number:** 1P01CA250972-01
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** Bryan Patrick Bednarz
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $293,681
- **Award type:** 1
- **Project period:** 2020-09-14 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10024892

## Citation

> US National Institutes of Health, RePORTER application 10024892, Advanced Imaging and Dosimetry Core (1P01CA250972-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10024892. Licensed CC0.

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