# Transcriptional Mechanism of BRD4 in Solid Tumor

> **NIH NIH R01** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $118,657

## Abstract

PROJECT SUMMARY
The research project planned in this diversity research supplement for Dr. Wilnelly Martinez-Ortiz
is constructed based on her research expertise in chemistry, computational structural biology and
molecular/cell biology and desire to further her postdoctoral training in chemical biology and small
molecule cancer drug discovery for epigenetic proteins. At the same time, this research project that is
being developed and refined by Dr. Martinez-Ortiz under the mentorship from Dr. Ming-Ming Zhou is
expected to facilitate the Zhou lab’s ongoing efforts in deciphering the fundamental molecular
mechanisms that underlie major transcription regulator proteins as they pertain to the epigenetic
regulation of gene transcription in biology and human cancers, as described in the parent grant
(1R01CA239165-01, PI: MMZ). Specifically, Dr. Wilnelly Martinez-Ortiz will employ the structure-based
rational design strategy to develop novel small molecule compounds, which will be used as powerful
research tools to study the functional role of BET transcription proteins as key components of the
important transcriptional activation complex for gene transcription in chromatin. We expect that this
planned research project will help prepare Dr. Wilnelly Martinez-Ortiz to become fully an independent
investigator in academic research, who will be capable of identifying most challenging problems in
biomedical research, and conceiving and developing scientific approaches to address such problems
in human biology and disease.

## Key facts

- **NIH application ID:** 10025103
- **Project number:** 3R01CA239165-02S1
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Ming-Ming Zhou
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $118,657
- **Award type:** 3
- **Project period:** 2019-03-01 → 2024-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10025103

## Citation

> US National Institutes of Health, RePORTER application 10025103, Transcriptional Mechanism of BRD4 in Solid Tumor (3R01CA239165-02S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10025103. Licensed CC0.

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