# Structural Circuits Core

> **NIH NIH P30** · UNIVERSITY OF MINNESOTA · 2020 · $399,682

## Abstract

PROJECT SUMMARY: Structural Circuits Core
Modern tissue clearing and imaging methods provide the potential for a wealth of information regarding nervous
system anatomy and function. However, to best utilize such methods, understanding the options for tissue
clearing, and the advantages and disadvantages of various imaging methods need to be appreciated.
Furthermore, data handling, analysis, and storage all provide significant obstacles when attempting to make full
use of the capabilities of these modern techniques.
The goal of the Structural Circuits Core (SCC) is to help researchers best utilize ultramodern technology for the
anatomical mapping of brain circuitry involved in drug addiction. In order to do so, the SCC partners with the
University Imaging Center (UIC), the University of Minnesota Informatics Institute (UMII), the Minnesota
Supercomputing Institute (SCI) and the Data Repository for the University of Minnesota (DRUM). The SCC
provides the infrastructure for automated use of brain clearing technology paired with meso- and micro-scale
imaging of the central nervous system. Importantly, the SCC helps tailor experiments to best utilize the most
appropriate methodological and technological approaches, and, integrating with the Addiction Connectome
Core, provides standardized resources for the analysis, storage, and distribution of these imaging datasets. The
SCC not only allows investigators to quickly and thoroughly interrogate their own data, but also allows
quantitative comparisons across laboratories through a common format structure and custom designed software.

## Key facts

- **NIH application ID:** 10025455
- **Project number:** 1P30DA048742-01A1
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** Paul G Mermelstein
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $399,682
- **Award type:** 1
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10025455

## Citation

> US National Institutes of Health, RePORTER application 10025455, Structural Circuits Core (1P30DA048742-01A1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10025455. Licensed CC0.

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