# Microbial multi-stress responses: from intracellular networks to communities

> **NIH NIH R35** · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2020 · $388,921

## Abstract

Project Summary/Abstract
 Bacteria mount a physiologic stress response to survive hostile or stringent conditions. These stress responses
shape the microbial communities that live in, on, and around us. Despite the importance of stress responses, we
know little about how microbes tolerate complex combinations of stressors.
 This proposal will answer three overarching questions regarding microbial stress responses. 1.) How do
bacteria response to multiple stressors? 2.) How does stress reshape the composition and stability of microbial
communities? 3.) How quickly can we learn the stress responses of newly discovered bacteria? In answering
these questions, several hypotheses will be evaluated using a consistent experimental and theoretical framework.
The stress response networks of pathogenic streptococci will be characterized across multiple scales. Long term,
our goal is to develop tools to analyze and target complex stress responses in the human microbiome.

## Key facts

- **NIH application ID:** 10029402
- **Project number:** 1R35GM138210-01
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
- **Principal Investigator:** Paul Anthony Jensen
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $388,921
- **Award type:** 1
- **Project period:** 2020-07-01 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10029402

## Citation

> US National Institutes of Health, RePORTER application 10029402, Microbial multi-stress responses: from intracellular networks to communities (1R35GM138210-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10029402. Licensed CC0.

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