# Induction and Patterning of Cardiogenic Fields

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $403,750

## Abstract

PROJECT SUMMARY/ABSTRACT
The cardiogenic fate is established as a bilateral heart field (HF) within the anterior mesoderm through an
inductive inter-germ layer signaling interaction. Many genetic pathways responsible for fate specification and
differentiation of the HF have been extensively studied. However, where cells of the HF originate, how they
precisely arrive at bilateral HF, or how they receive fate specification cues, remains obscured. Using live imaging
of both wild type and somatic trans-genetic embryos with molecular sensors, this proposal will identify a coupling
of: axis inducing signals with HF precursor positioning in the PS (Aim 1), the earlier onset of bilateral patterning
(Aim 2); and a direct cell-cell contact with HF fate specification signaling transfer (Aim 3). Taken together, the
proposed study will establish a novel view for the importance of coordinated positioning and interactions in the
PS and at the HF forming site to define ultimate cardiogenic fate.

## Key facts

- **NIH application ID:** 10033231
- **Project number:** 1R01HL153736-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Takashi Mikawa
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $403,750
- **Award type:** 1
- **Project period:** 2020-08-28 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10033231

## Citation

> US National Institutes of Health, RePORTER application 10033231, Induction and Patterning of Cardiogenic Fields (1R01HL153736-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10033231. Licensed CC0.

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