# Core 1: Biospecimen/Pathology

> **NIH NIH P20** · DUKE UNIVERSITY · 2020 · $98,196

## Abstract

ABSTRACT – Biospecimen/Pathology Core (Core 1)
The Biospecimen/Pathology Core of the Duke Cancer Health Disparities P20 SPORE (DCHD) leverages and is
housed in the Duke Cancer Institute’s BioRepository & Precision Pathology Center (BRPC). The BRPC is a
Shared Resource of the Duke Cancer Institute and supported in part by the Duke Cancer Center Support Grant
(5P30-CA014236-45). This NCI-funded shared service center obtains broad consent from patients for blood and
tissue sample donation and procures, processes and banks both liquid and tissue biospecimens, supports
Duke’s “living biobank” with the Duke Patient-Derived Xenograft and Primary Tumor Cell Culture Services, and
implements bioinformatic and clinical strategies for precise sample and model annotation. For the DCHD, the
Core will efficiently provide high-quality tissue, blood and fluid-based biospecimens and processing services to
requesting investigators, and continue to adjust practices as researcher needs evolve (Aim 1); support current
and future DCHD P20 projects through expansion of existing best practices in tissue procurement, processing,
and sample management (Aim 2); and educate the local, regional and national community on the importance of
available biospecimens in biomedical research to enhance availability of specimens and data from
underrepresented minorities (Aim 3). The Duke BRPC has recently been awarded an NCI UM1 to join the
Cooperative Human Tissue Network (CHTN)(www.chtn.org); this network of biorepositories will support
deeper cohort generation from across the country. For the proposed Projects, we will provide appropriate
lung cancer specimens and associated data from multiple races/ethnicities (Project 1), and stomach biopsies
positive for H. pylori from Black patients (Project 2). The needs of future Pilot Projects will be assessed for
feasibility; given the BRPC’s existing library, a recent focus on underrepresented minority inclusion, and CHTN
participation, a wide range of cancer disparities research should be possible. This Core is fully integrated into
the DCHD and is critical for its success.

## Key facts

- **NIH application ID:** 10037510
- **Project number:** 1P20CA251657-01
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Shannon Jones McCall
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $98,196
- **Award type:** 1
- **Project period:** 2020-09-14 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10037510

## Citation

> US National Institutes of Health, RePORTER application 10037510, Core 1: Biospecimen/Pathology (1P20CA251657-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10037510. Licensed CC0.

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