# Computerized tests of cognitive decline in presymptomatic Alzheimer’s disease

> **NIH NIH R44** · NEUROBEHAVIORAL SYSTEMS, INC. · 2020 · $202,318

## Abstract

Abstract. We are requesting an administrative supplement to expand participant recruitment
and testing to the VA Northern California Healthcare System (VANCHCS) in Martinez. The
supplement would reduce five potential risks to the long-term scientific impact of second
generation California Cognitive Assessment Battery (CCAB-2) tests:
• Recruitment. Participant recruitment has been compromised by the establishment of a
 California-funded Alzheimer’s Disease Research Center at our original recruitment site.
 Expanding recruitment and testing to the VANCHCS will resolve this problem and increase
 participant diversity: there are more than 32,000 eligible older participants within the
 VANCHCS catchment who meet study inclusion criteria.
• Milestone completion. Our research plan calls for nearly 5,000 assessments over three
 years, with nearly 2,300 assessments planned in Phase II, year 1. This would require 9.1
 assessments per day during year 1, i.e. approximately 20 hours of testing. The assistance of
 trained VA staff and the established VANCHCS’ infrastructure will assist us in meeting these
 testing challenges.
• CCAB-2 compatibility with hospital data security protocols. In the original application,
 CCAB-2 testing was limited to NBS offices. The supplement will support the software
 development and testing needed to ensure that CCAB-2 tests function within secure
 healthcare IT networks with extensive data protection safeguards and HIPAA-compliant
protocols.
• CCAB-2 usability and robustness. In the original application, CCAB-2 test administration
 was limited to NBS personnel. This administrative supplement will enable extensive field
 testing by VA scientists and clinicians to ensure CCAB-2 robustness and usability prior to
 commercial launch.
• Disseminating results. The extensive testing demands in the original application would limit
 NBS scientific outreach. The supplement will support VA scientists in publicizing CCAB-2
 capabilities at conferences, Alzheimer’s Disease Centers, grand rounds, research labs,
 department colloquia, and in peer-reviewed publications.

## Key facts

- **NIH application ID:** 10039211
- **Project number:** 3R44AG062076-02S1
- **Recipient organization:** NEUROBEHAVIORAL SYSTEMS, INC.
- **Principal Investigator:** Peter Pebler
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $202,318
- **Award type:** 3
- **Project period:** 2019-12-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10039211

## Citation

> US National Institutes of Health, RePORTER application 10039211, Computerized tests of cognitive decline in presymptomatic Alzheimer’s disease (3R44AG062076-02S1). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/10039211. Licensed CC0.

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