# Leukocyte trafficking in thoracic grafts

> **NIH VA I01** · ST. LOUIS VA MEDICAL CENTER · 2020 · —

## Abstract

   
DESCRIPTION (provided by applicant):    
   
Myocardial ischemia reperfusion injury, a consequence of organ preservation and implantation, adversely impacts both early and late outcomes after heart transplantation. As heart failure is highly prevalent among the veteran population, this area of investigation is of very high significance. While neutrophils are critical mediators of myocardial ischemia reperfusion injury, little is known about their trafficking and activation requirements during this form of sterile inflammation. Utilizing our newly developed technique of intravital imaging of beating mouse hearts, we have uncovered a role for innate immune molecules in donor hearts for entry of neutrophils into the graft tissue of freshly reperfused cardiac transplants. This application proposes to study mechanisms for neutrophil recruitment during myocardial ischemia reperfusion injury of heart grafts and will allow for the development of new therapeutic strategies.

## Key facts

- **NIH application ID:** 10039494
- **Project number:** 5I01BX002730-05
- **Recipient organization:** ST. LOUIS VA MEDICAL CENTER
- **Principal Investigator:** Daniel Kreisel
- **Activity code:** I01 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2020
- **Award amount:** —
- **Award type:** 5
- **Project period:** 2015-10-01 → 2021-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10039494

## Citation

> US National Institutes of Health, RePORTER application 10039494, Leukocyte trafficking in thoracic grafts (5I01BX002730-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10039494. Licensed CC0.

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