# The Role of Glycolysis in Axon Development

> **NIH NIH R21** · TEMPLE UNIV OF THE COMMONWEALTH · 2020 · $435,875

## Abstract

Axon extension, retraction and regeneration are energy dependent processes. ATP is the main
form of cellular energy and it is generated through oxidative phosphorylation, in the mitochondrion,
and glycolysis. This project aims to pioneer investigations into the role of glycolysis in neuronal
morphogenesis with emphasis on axon development. The project also addresses the role of
glycolysis in the response of axons to injury. In both contexts, the project also aims to determine if
axonally targeted mRNAs encoding glycolytic enzymes undergo axonal translation in response to
extracellular signals and injury.

## Key facts

- **NIH application ID:** 10040537
- **Project number:** 1R21NS118000-01
- **Recipient organization:** TEMPLE UNIV OF THE COMMONWEALTH
- **Principal Investigator:** GIANLUCA GALLO
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $435,875
- **Award type:** 1
- **Project period:** 2020-08-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10040537

## Citation

> US National Institutes of Health, RePORTER application 10040537, The Role of Glycolysis in Axon Development (1R21NS118000-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10040537. Licensed CC0.

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