# The Effect of 17q21 Locus SNPs on Targeted Host Immune Responses in Children With Rhinovirus-induced Exacerbations of Asthma

> **NIH NIH R21** · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2020 · $240,794

## Abstract

Project Summary
It is the long-term goal of this study is to elucidate mechanistic drivers of rhinovirus (RV)-associated development
and exacerbations of asthma to inform clinical prevention and therapeutic management strategies. Towards this
end, we will investigate the functional impact of genetic variations in the previously identified increased risk 17q21
locus in children with asthma during RVA and RVC infections. Numerous genetic studies have revealed an
increased risk of the development of asthma with genetic variations in the GSDMB/ORMDL3 locus located on
17q21. To do this, we will develop and validate a RNA capture probeset for RNAseq which will allow for the
simultaneous evaluation of rhinovirus infection and gene expression of the GSDMB, ORMDL3, ICAM1, IL17,
and type I interferon pathways. After validation of this method in vitro, we will use it to elucidate gene expression
from clinical samples obtained from children during acute RV infections with and without established 17q21 risk
polymorphisms. We will examine if there is differential upregulation of pro-inflammatory pathways that are
established contributors to the development and exacerbations of asthma between infections with RVA and RVC
infections to determine the impact of the genetic variations in the 17q21 locus. Taken together, this data will
provide unprecedented insight into the consequences of genetic variation in the 17q21 locus in a pediatric
asthmatic population during acute RV infection.

## Key facts

- **NIH application ID:** 10041579
- **Project number:** 1R21AI154127-01
- **Recipient organization:** UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
- **Principal Investigator:** Darrell L Dinwiddie
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $240,794
- **Award type:** 1
- **Project period:** 2020-07-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10041579

## Citation

> US National Institutes of Health, RePORTER application 10041579, The Effect of 17q21 Locus SNPs on Targeted Host Immune Responses in Children With Rhinovirus-induced Exacerbations of Asthma (1R21AI154127-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10041579. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*