# Retinal vessel features as a marker of idiopathic intracranial hypertension treatment response: a secondary analysis of the idiopathic intracranial hypertension treatment trial

> **NIH NIH R21** · STANFORD UNIVERSITY · 2020 · $301,263

## Abstract

PROJECT SUMMARY
There is a critical need for developing markers and predictors of both high intracranial pressure (ICP) and response to
high ICP treatment, that will guide clinicians to appropriately personalize treatment for idiopathic intracranial
hypertension (IIH) by targeting aggressive interventions to patients who are not responding to conservative treatments
or are at risk of vision loss. This application seeks to develop measurements of retinal vascular changes in the posterior
eye as novel clinically-relevant biomarkers to meet this need. These are promising biomarker candidates based on
preliminary data. Furthermore, they are specific, objective, quantitative and can be derived from non-invasive
technologies. The long-term goal of this research is to understand the time course and variability of retinal vascular
changes associated with ICP changes. Though some retinal vascular changes in association with ICP have been described,
others have not been systematically studied. Furthermore, how retinal vascular changes relate to other eye changes
associated with ICP is poorly understood. Our central hypothesis is that retinal vascular changes in response to ICP
treatment precede other ophthalmic changes and that these predict treatment response over the longer term. The
objective of this proposal is to perform a secondary analysis of fundus photos collected as part of the NIH funded
Idiopathic Intracranial Hypertension Treatment Trial (IIHTT, clinicaltrials.gov identifier NCT01003639) to define retinal
vascular changes occurring during IIH treatment in the context of other markers of disease. The first aim is to define the
spectrum of retinal vascular changes that occur during medical treatment of IIH by comparing retinal vascular features
extracted from fundus photographs at baseline and study conclusion. The second aim is to establish early retinal
vascular change as a marker of response to medical treatment in IIH by studying how changes between initial study visits
(0-1 month) predict outcomes at 6 months.

## Key facts

- **NIH application ID:** 10043677
- **Project number:** 1R21EY031726-01
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Heather Elspeth Moss
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $301,263
- **Award type:** 1
- **Project period:** 2020-08-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10043677

## Citation

> US National Institutes of Health, RePORTER application 10043677, Retinal vessel features as a marker of idiopathic intracranial hypertension treatment response: a secondary analysis of the idiopathic intracranial hypertension treatment trial (1R21EY031726-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10043677. Licensed CC0.

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