# The role of arteriogenesis on structural and functional neurovascular recovery after cerebral stroke

> **NIH NIH R21** · J. DAVID GLADSTONE INSTITUTES · 2020 · $493,050

## Abstract

SUMMARY
Cerebral stroke leads to long-term disability, yet post-stroke treatment remains primarily limited to
rehabilitation. The partial functional recovery that does occur is due in part to neurovascular plasticity of the
brain region adjacent to stroke damage—the peri-stroke penumbra. However, attempts to manipulate the
neurovasculature post-stroke by promoting angiogenesis—sprouting of new capillary vessels—have not been
successful, in part because angiogenesis can lead to tortuous, leaky vessels that do not increase blood flow.
Alternatively, arteriogenesis—the generation of large-bore vessels in response to shear stress—could play
an important role in post-stroke recovery and represent a novel therapeutic target. However, the lack of tools
to specifically manipulate arteriogenesis has hampered efforts to test this hypothesis. We identified Dach1 as
an endothelial transcription factor as a tool to specifically drive arteriogenesis. Here, we will use new mouse
models that allow us to bi-directionally control Dach1 levels in endothelial cells, to determine to what extent
arteriogenesis is involved in post-stroke recovery of brain functions. Specifically, we will examine the links
between arteriogenesis and post-stroke recovery of the vascular network (Aim 1), neurovascular coupling
(Aim 2), and behavior (Aim 3).
Our long-term goal is to understand the mechanisms of adaptive post-stroke neurovascular plasticity to
develop new treatments and improve brain health. Funding of this proposal will enable an unbiased study of
the brain following stroke with unprecedented temporal and spatial resolution in freely behaving animals,
identify the specific role of arteriogenesis in post-stroke recovery, and may unveil new therapeutic targets that
enhance the therapeutic window of post-stroke rehabilitation, which is a key limiting factor in treating stroke
patients.

## Key facts

- **NIH application ID:** 10043803
- **Project number:** 1R21NS118379-01
- **Recipient organization:** J. DAVID GLADSTONE INSTITUTES
- **Principal Investigator:** Jeanne T Paz
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $493,050
- **Award type:** 1
- **Project period:** 2020-05-15 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10043803

## Citation

> US National Institutes of Health, RePORTER application 10043803, The role of arteriogenesis on structural and functional neurovascular recovery after cerebral stroke (1R21NS118379-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10043803. Licensed CC0.

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