# Oklahoma Nathan Shock Center of Excellence in Basic Biology of Aging

> **NIH NIH P30** · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2020 · $1,060,577

## Abstract

The Oklahoma Shock Nathan Shock Center is designed to deliver unique, innovative services that are not
currently available at most institutions or at other Shock Centers. The focus of the Center is on the development
of careers of young investigators but our services are accessible by the entire research community studying
aging and Geroscience. The Oklahoma Shock Center is unique in that it focuses on the field of Geroscience and
has institutional support from the three major research institutions in Oklahoma City: the University of Oklahoma
Health Science Center, the Oklahoma Medical Research Foundation, and the Oklahoma City VA Medical Center.
Over the past four years, more than 75% of the Pilot Grants awarded by the Research Development Core and
almost 40% of all services provided researchers by the Research Cores have been provided to investigators at
institutions other than the host institutions. The 2020 Oklahoma Nathan Shock Center has six Cores. The
Program Enhancement Core oversees all the activities of the Shock Center and organizes the annual
Oklahoma GeroScience Symposium, which provides travel awards to graduate students and fellows from other
institutions to attend the Symposium. The Geropathology Research Resource in the Core provides investigators
with pathological assessments of mice using the Geropathology Grading Platform. The Research Development
Core is an innovative departure from the traditional structure of similar Cores in Nathan Shock Centers and is
designed to provide unprecedented service to the scientific community throughout the nation. The Multiplexing
Protein Analysis Core provides investigators novel mass spectrometry methods for measuring the abundance
of proteins from any tissue/cell from any organism that has its genome sequenced. The Core can quantify panels
of ~50 proteins in a single run. Using D2O labeling, the Core can also measure the synthesis and turnover of
these proteins. In combination, these analyses facilitate interrogation of proteomic changes in pathways
of importance to aging and Geroscience. The Genomic Sciences Core has developed assays to measure
both the methylation and hydroxymethylation of DNA at specific sites in the genome, which will be
available to investigators studying epigenetics of aging. The Core also offers researchers the
comprehensive analysis of mitochondrial genome heteroplasmy (variants/mutations and deletions) and copy
number as well as single-cell transcriptomics assays. The Geroscience Redox Biology Core provides
investigators with measures of oxidative damage, redox couples, and mitochondrial function, which
require specialized instrumentation and expertise. The Core also provides investigators with the latest
technology to measure reactive oxygen species in vivo and in situ in tissues of rodents. The
GeroInformatics Core provides investigators assistance in the analysis of large datasets, statistical
support, analysis of high-throughput datasets including single-cell t...

## Key facts

- **NIH application ID:** 10044523
- **Project number:** 2P30AG050911-06
- **Recipient organization:** UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- **Principal Investigator:** ARLAN G. RICHARDSON
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,060,577
- **Award type:** 2
- **Project period:** 2015-07-15 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10044523

## Citation

> US National Institutes of Health, RePORTER application 10044523, Oklahoma Nathan Shock Center of Excellence in Basic Biology of Aging (2P30AG050911-06). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10044523. Licensed CC0.

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