The Program Enhancement Core is the administrative arm of the Oklahoma Nathan Shock Aging Center and will oversee all activities conducted by the Center at the University of Oklahoma Health Sciences Center, the Oklahoma Medical Research Foundation, and the Oklahoma City VA Medical Center. The Core will promote/publicize the services of the Research Cores as well as evaluate their performance. The Program Enhancement Core will also administer two novel programs: an annual Oklahoma GeroScience Symposium and the Geropatholgy Research Resource. The specific aims of the Program Enhancement Core are: Aim 1. To provide administrative/management support for the Center. The Core will be responsible for the day-to-day management of the center; will oversee budgets, including cost recovery for the Research Cores; and will promote the integration of services among the Research Cores. In addition, the Program Enrichment Core will evaluate the progress or the Center in two ways: an Internal Advisory Committee consisting of administrators and research leaders at the three host institutions that will annually evaluate the Center and the External Advisory Committee consisting of five leaders in aging who will evaluate the Center every other year . Aim 2. To promote/publicize services and activities provided by the Cores. The Core will be responsible for making the scientific community aware of services provided by the Research Cores through a series of mechanisms, e.g., a website, the Shock Centers Coordinating Center with the American Federation for Aging Research, and Core Leaders attending aging meetings such as the Gordon and Keystone Conferences and the annual meetings of the American Aging Association and Gerontological Society of America. Aim 3. To provide the intellectual and organizational leadership to stimulate interest in aging and geroscience in Oklahoma and the nation. Interest in aging and geroscience in Oklahoma City and Oklahoma as well as the nation will be stimulated through a variety of activities, e.g., organizing a seminar series in aging at OUHSC/OMRF, hosting the Summer Training Course in Experimental Aging Research when it is in Oklahoma City, and participating in the bi-annual Nathan Shock Summits at the annual meeting of the American Aging Association. Most important will be the annual Oklahoma GeroScience Symposium, which will be organized and managed by the Program Enhancement Core. Aim 4. To provide investigators with pathological analysis specifically designed for studying aging mice through the Geropathology Research Resource (GRR). The GRR will provide investigators with the unique geropathological analysis developed by the Geropathology Research Network, which will allow investogators to evaluate the effect of age and aging interventions on the pathological status of mice. The GRR will also collaborate with the University of Washington Shock Center to continue the functions of the Geropathology Research Network and promote th...