# Cellular Senescence and Beyond Core

> **NIH NIH P30** · BUCK INSTITUTE FOR RESEARCH ON AGING · 2020 · $42,857

## Abstract

ABSTRACT
 Cell fates are important intermediates between age-related molecular events, including damage and
stress, and the phenotypes and pathologies that are hallmarks of aging organisms. Cell fates can also offer
unique -- and broadly applicable -- opportunities for interventions into many age-related diseases. The
Cellular Senescence and Beyond Core (CSB) in this Nathan Shock Center (NSC) application will help
academic researchers determine whether and to what extent specific cell fates play a role in their aging and/or
intervention models. Depending on the project, the Core will characterize cell autonomous and non-
autonomous features of selected cell fates, advise investigators of their possible physiological consequences,
and test proposed intervention strategies. Aim 1 will establish and offer standardized methods to detect cell-
associated markers of the cell fate decisions of cellular senescence, cell death and cell competition. Aim 2 will
establish standardized methods to detect and assess the impact of the cell non-autonomous effects resulting
from the cell fate decisions of cellular senescence, cell death and cell competition. The core will employ a
variety of techniques, including ELISAs, immunocytochemistry, western analyses and, of particular utility, mass
spectrometry to provide comprehensive, unbiased assessments. The Core will also advise investigators on
strategies to identify the most promising cell autonomous and non-autonomous acting candidates and perform
relevant assays to test these candidates for biological activity. In summary, the proposed Cellular
Senescence and Beyond Core will provide investigators in aging research with a broad array of experimental
assays and advice on how to determine whether and to what extent selected cell fate decisions are important
contributors to the age-related phenotypes and pathologies of interest to the investigators.

## Key facts

- **NIH application ID:** 10044923
- **Project number:** 1P30AG068345-01
- **Recipient organization:** BUCK INSTITUTE FOR RESEARCH ON AGING
- **Principal Investigator:** Judith Campisi
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $42,857
- **Award type:** 1
- **Project period:** 2020-09-15 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10044923

## Citation

> US National Institutes of Health, RePORTER application 10044923, Cellular Senescence and Beyond Core (1P30AG068345-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10044923. Licensed CC0.

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