# Adipose Tissue Core

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $157,404

## Abstract

Abstract/Summary - ATC
Adipose tissue is composed of a wide range of cell types (e.g. adipocytes, fibroblasts, stem
cells, leukocytes) that control the ability of adipose tissue to store nutrients and regulate
metabolism. Obesity leads to qualitative and quantitative alterations in all AT cell types that
depends on location in the body, metabolic state, and sex. The fundamental role of adipose
tissue expansion in obesity requires investigators access to the reagents, techniques, and
assays to evaluate adipocyte size, adipose tissue inflammatory tone, lineage relationships
between cell types, and metabolic function in pre-clinical mouse models as well as human
samples. The high lipid content of adipose tissue and the challenges in tissue processing limit
the broad application of rigorous adipose tissue assessments in research studies leading to
many gaps in the field of obesity research. The Adipose Tissue Core (ATC) was established to
address these gaps has assisted a range of investigators incorporate adipose tissue
assessments in their conceptual models and experiments. The aims of the ATC are (1) To
provide consultation and training on rigorous experimental approaches to investigate how
adipocytes develop, function, and interact with other cell types through paracrine and endocrine
mechanisms. (2) To provide access to the specialized techniques required to rigorously
evaluate adipose tissue biology. (3) To provide investigators with tissues, cells, databases,
state-of-the-art assays, histological and other equipment, and animal models for the study of
adipose tissue function. (4) To develop and implement new technologies beneficial to MNORC
investigators interested in adipose tissue biology. Services will be offered to investigators in line
with these aims with oversight from experts in adipose tissue biology to ensure rigorous and
reproducible application of state of the art approaches to assess adipose tissue function in
mouse and human samples.

## Key facts

- **NIH application ID:** 10045296
- **Project number:** 2P30DK089503-11
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Ormond A MacDougald
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $157,404
- **Award type:** 2
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10045296

## Citation

> US National Institutes of Health, RePORTER application 10045296, Adipose Tissue Core (2P30DK089503-11). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10045296. Licensed CC0.

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