# San Antonio Nathan Shock Center of Excellence in the Biology of Aging

> **NIH NIH P30** · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2020 · $976,740

## Abstract

With its evolving Cores, enrichment and training programs, and supported research projects, the San Antonio
(SA) Nathan Shock Center has for ~25 years provided critical support to investigators locally, nationally and
abroad. With its existing and growing intellectual capital, the SA Shock Center is poised to provide (1) an
enhanced platform to conduct horizontally-integrated (lifespan, healthspan, pathology, pharmacology)
transformative research in the biology of aging, and (2) a springboard for advanced educational and training
activities. The Specific Aims of the SA Nathan Shock Center are:
1. To be a leader in research that advances our understanding of the biology of aging
2. To provide a `one-stop-shop' venue to accelerate transformative research in the biology of aging
3. To foster and promote career development of early-stage investigators in aging biology
4. To serve as a resource and partner to investigators from other Shock Centers, institutions, and the public, for
dissemination of scientific knowledge and enhancing awareness about aging research
 To achieve these objectives we have leveraged and streamlined our resources and strengths to create six
interrelated cores: 1) Administration and Program Enrichment Core; 2) Research Development (RD) Core; 3)
Aging Animal Models and Longevity Assessment Core; 4) Integrative Physiology of Aging Core (IPAC); 5)
Pathology Core; and 6) the Analytical Pharmacology and Drug Evaluation Core. These cores will provide an
integrated venue to conduct and facilitate carefully phenotyped and well-integrated (i.e. lifespan, healthspan,
pathology) aging studies. Using these cores, we will apply genetic, biochemical, and pharmacologic
methodologies to several vertebrate animal models including rodents (mice, rats, mole-rats), and marmosets.
Based on our past experiences and successes, we fully anticipate that our enhanced platform and training
activities will greatly facilitate the identification of molecular and cellular mechanisms that influence aging. This
approach will result in novel strategies and the identification of (pharmacologic) targets to extend healthy life
expectancy.
 The SA Shock Center is built on a unique foundation provided by UTHSCSA's exceptional and tightly
integrated resources: a Claude D. Pepper Older Americans Independence Center (OAIC), a site of the
Interventions Testing Program (ITP), a Geriatric Research, Education and Clinical Center (GRECC), a T32
Training Grant on Geroscience, and a robust Barshop Institute that unites aging research at UTHSCSA. We are
the only Shock Center with all of these synergistic components available. In addition, the SA Shock Center
receives unparalleled institutional commitment (~$500,000/year), including a new ~$100M 109,000 sq. ft.
building – specific for the Barshop Institute – that will house the Shock Center, the Claude Pepper OAIC and the
ITP in a centrally located facility.

## Key facts

- **NIH application ID:** 10045446
- **Project number:** 2P30AG013319-26
- **Recipient organization:** UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- **Principal Investigator:** PETER J HORNSBY
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $976,740
- **Award type:** 2
- **Project period:** 1997-07-15 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10045446

## Citation

> US National Institutes of Health, RePORTER application 10045446, San Antonio Nathan Shock Center of Excellence in the Biology of Aging (2P30AG013319-26). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10045446. Licensed CC0.

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