# Urban air pollution and neurobehavioral trajectories in the ABCD study > **NIH NIH R01** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2020 · $688,892 ## Abstract Project Summary Fine particulate matter (aerodynamic diameter<2.5 μm; PM2.5) is a novel and ubiquitous environmental neurotoxin affecting neurobehavioral development of millions of American children living in urban areas. However, our review points to several major methodological limitations and critical knowledge gaps in the extant literature, including: 1) the lack of studies with longitudinal brain and behavior assessments; 2) relatively small samples from localized geographical areas; 3) little to no information on long-term cumulative and/or differential timing of exposure across development; and 4) remaining questions regarding the neurotoxicity of PM2.5 exposure on critical neurobehavioral processes that continue to mature across adolescence. Although animal neurotoxicology studies have highlighted the importance of sex, there is only limited epidemiologic evidence for sex difference in PM2.5 neurotoxicity in children. Moreover, brain development is also shaped by family- and community-level social factors, but whether and how air pollution neurotoxicity interacts with the social context remains unclear. This application will leverage the nationwide longitudinal Development (ABCD) study of 9- and 10-year-olds (N=11,873) Adolescent Brain Cognitive to examine prenatal and childhood air pollution exposure effects on neurobehavioral development in boys and girls across 21 U.S. cities. ABCD outcome measures are anchored on the transition to early adolescence because neuromaturation continues from childhood through early adulthood, making such developmental transition periods potentially more vulnerable to environmental insults. Our primary exposure of interest is PM2.5, but advances in well-validated spatiotemporal modeling tools will also allow us to explore neurotoxicity of PM composition and other gaseous pollutants (i.e. NO2, O3). Given the reconstructed exposure histories from gestation to childhood to early-adolescence, we will: (a) determine long-term cumulative exposure effects; and (b) examine differential exposure effects across sensitive time windows to better define PM2.5 neurotoxicity on executive functioning (EF) and emotional behaviors from ages 9 to 12 years-old (Aim 1); and also understand how the resulting neurotoxicity influences structural and functional brain development, including brain morphology, white matter microstructure, brain activity at rest and during EF and emotion-focused tasks, and functional connectivity of large-scale networks (Aim 2). In Aim 3, we will evaluate if children are more susceptible to PM2.5 effects based on: a) sex and SES; and b) family- and neighborhood-level contextual risk and protective factors. This application will advance our understanding of air pollution neurotoxicity on adolescent brains, as well as how exposure effects may vary across sensitive time windows of development and/or differ by individual susceptibility. The resulting new knowledge will contribute to sciences-based air poll... ## Key facts - **NIH application ID:** 10045490 - **Project number:** 1R01ES031074-01A1 - **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA - **Principal Investigator:** Megan Marie Herting - **Activity code:** R01 (R01, R21, SBIR, etc.) - **Funding institute:** NIH - **Fiscal year:** 2020 - **Award amount:** $688,892 - **Award type:** 1 - **Project period:** 2020-09-09 → 2025-06-30 ## Primary source NIH RePORTER: https://reporter.nih.gov/project-details/10045490 ## Citation > US National Institutes of Health, RePORTER application 10045490, Urban air pollution and neurobehavioral trajectories in the ABCD study (1R01ES031074-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10045490. Licensed CC0. --- *[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*