# RAE Health I-Corps

> **NIH NIH R44** · CONTINUEYOU, LLC · 2020 · $55,000

## Abstract

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PROJECT SUMMARY
The research project outlined in this SBIR submission will develop the Realize, Analyze, Engage (RAE)
platform into a tool to promote sustained recovery in individuals receiving treatment for substance use disorder.
In this proposal, the investigators intend to deploy the RAE system- consisting of a wearable sensor, a
smartphone app, and a clinical portal- to provide individuals in recovery and their treatment providers with an
opportunity to identify moments of high risk for relapse and to access real time intervention opportunities.
Wearable biosensors are small, noninvasive devices that continuously record physiology. These sensors have
the ability to detect digital biomarkers of drug use, craving and stress, the latter of which herald an increased
risk of relapse. RAE aims to utilize this capability to create a real-time solution for individuals in recovery. The
components of RAE are: 1) The Empatica Embrace and/or Garmin VivoSmart, a wrist mounted sensor similar
in form factor to a smart watch, that continuously monitors skin temperature, electrodermal activity (EDA) and
locomotion. Detection algorithms for stress, craving and drug use will be embedded on the Embrace
firmware. 2) The RAE smartphone application (app), for the individual in recovery. The app will be triggered
either by detection of an event on the Embrace or manually by the user when needed and will provide multiple
options for annotations, stress reduction techniques and immediate contact with individuals in the pre-defined
support system via call or SMS text. The app will also log sleep, physical activity, and geographic location of
events. 3) The RAE Portal, for the treatment provider, will deliver alerts when an event is detected on the
user’s device for the opportunity to intervene in real time and will also provide metrics on the user’s recorded
activities. The research plan has two Specific Aims: Aim 1) Technology Deployment: To deploy and optimize
the RAE system in a population of individuals in treatment for substance use disorder and Aim 2) Aim 2:
Technology Evaluation and Optimization: To evaluate the compliance, usability and accuracy of the RAE
system To achieve these aims, the investigators will first deploy the technology in a population of individuals in
recovery and collect data on accuracy, usability and functionality (Aim 1). The data from Aim 1 will be used to
optimize the system and achieve millstones in Aim 2 which will include sensitivity, specify, accuracy and user
compliance targets. The investigators have assembled a leadership team and advisory team with the
necessary expertise in business, medicine, wearable technology and engineering to develop RAE into a tool
that dramatically improves the success of treatment for substance use disorder, promotes sustained sobriety,
and reduces morbidity and mortality from relapse to substance use.
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## Key facts

- **NIH application ID:** 10045689
- **Project number:** 3R44DA046151-01S1
- **Recipient organization:** CONTINUEYOU, LLC
- **Principal Investigator:** STEPHANIE P CARREIRO
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $55,000
- **Award type:** 3
- **Project period:** 2019-06-15 → 2020-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10045689

## Citation

> US National Institutes of Health, RePORTER application 10045689, RAE Health I-Corps (3R44DA046151-01S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10045689. Licensed CC0.

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