# Enantioselective Catalytic Chlorosilane Reactions

> **NIH NIH R15** · FLORIDA INSTITUTE OF TECHNOLOGY · 2020 · $434,610

## Abstract

Hypervalent silicon complexes generated from Lewis base catalysts and chlorosilanes
are very reactive intermediates and continue to be an important source for the
development of new chemical methodologies in organic synthesis. The unique reactivity
profiles, non-toxicity and ready availability of chlorosilanes have yielded an impressive
array of chemical methods and processes. This proposal seeks to innovate the ability of
chlorosilanes to deliver carbon nucleophiles under Lewis base catalysis conditions
through integrated experimental and computational investigations, and to apply it to
novel condensation reactions with readily available non-activated ketones and ketimines.
These challenging transformations will be rendered enantioselective through the
development of conceptually new classes of chiral Lewis base catalysts. The utility of the
resulting methods will be demonstrated by the asymmetric synthesis of pharmaceuticals
and biologically relevant molecules. Goals of the research program include advancing
Lewis base catalysis of chlorosilanes at the fundamental level, and new reaction
development that will provide rapid, efficient access to novel chiral building blocks
bearing the oxygen- and nitrogen-substituted quaternary stereocenters. We will focus on
the transformations that can provide chiral synthetic intermediates that are either
inaccessible or very difficult to obtain with currently available methods. The results are
expected to transform the way chlorosilanes are utilized in asymmetric synthesis.

## Key facts

- **NIH application ID:** 10046812
- **Project number:** 1R15GM139087-01
- **Recipient organization:** FLORIDA INSTITUTE OF TECHNOLOGY
- **Principal Investigator:** Roberto Peverati
- **Activity code:** R15 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $434,610
- **Award type:** 1
- **Project period:** 2020-08-01 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10046812

## Citation

> US National Institutes of Health, RePORTER application 10046812, Enantioselective Catalytic Chlorosilane Reactions (1R15GM139087-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10046812. Licensed CC0.

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