# BLR&D Research Career Scientist Award Application

> **NIH VA IK6** · VETERANS AFFAIRS MED CTR SAN FRANCISCO · 2021 · —

## Abstract

Prostate, kidney and bladder cancers (urological malignancies) are the most common
cause of death among our Veterans. Therefore, there is an urgent unmet need for the
management of these malignancies. To address these issues, the applicant has been working in
the field of urological malignancies since 1987. There are three main goals of the applicant's
research: 1) To investigate the molecular mechanisms of initiation, progression and metastasis
of urological malignancies. 2) To identify molecular biomarkers for diagnosis and prognosis of
urological cancers. 3) Treatment of urological cancers using natural compounds. To accomplish
these goals, the applicant has received several VA and NIH funded projects in collaboration with
VA and Non-VA clinicians and scientists.
 The applicant has been very productive with 350 scientific publications in peer-reviewed
journals and has had a distinguished career for 27 years in the VA system. Throughout his career,
he has been at the forefront of research into the molecular mechanisms of urological cancers. His
research work is supported by several NIH/VA funded projects and currently, he has one VA Merit
Review award and two NIH funded RO1 projects. He has trained more than 50 fellows and most
of them are faculty members at various institutions with funded research programs.
 The applicant has extensively collaborated with VA investigators and non-VA investigators
in funded program projects and scientific publications. The applicant was the first one to receive
a REAP (Research Enhancement Award Program) on prostate cancer from the Department of
Veterans Affairs (PI: Dahiya, 1999-2012). He has trained several scientists in collaboration with
VA clinician scientists.
 Recently, the applicant received a VA program project on the “Role of genetic biomarkers
in clinical assessment of prostate cancer” (PIs: Dahiya, Tanaka, Lau, 10-2012-09-2017) in
collaboration with four VA scientists and clinicians. Under this program, his team has investigated
whether SNPs, CpG methylation, miRNAs and X-linked genes together can predict which
localized prostate cancer patients have a higher risk of developing metastasis and thus require
more aggressive interventions.
 Currently, the applicant has a VA Merit Review award “ Regulation of c-Myc/HIF pathway
in the management of kidney cancer” (PI: Dahiya, 10/2011-09/2020) and two NIH RO1 projects
UO1CA184966 “Genetic factors for race related prostate cancer” (PI: Dahiya 07/2015-06/2020)
and RO1CA199694 “Molecular biomarkers for kidney cancer prognosis using non-coding RNAs
(PI: Dahiya 06/2016-05/2021)
 In summary, the applicant's scientific contributions are vitally important to the VA mission.
He has made ground breaking discoveries in the field of urological cancers and has also provided
significant resources to the scientific community and the VA system. The applicant's laboratory
has made several significant contributions to the fields of epigenetics (DNA methylation, histone
mod...

## Key facts

- **NIH application ID:** 10047723
- **Project number:** 5IK6BX004473-03
- **Recipient organization:** VETERANS AFFAIRS MED CTR SAN FRANCISCO
- **Principal Investigator:** RAJVIR DAHIYA
- **Activity code:** IK6 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2021
- **Award amount:** —
- **Award type:** 5
- **Project period:** 2018-10-01 → 2021-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10047723

## Citation

> US National Institutes of Health, RePORTER application 10047723, BLR&D Research Career Scientist Award Application (5IK6BX004473-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10047723. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*