# Environmental Influences on Childhood Outcomes in the Northern Plains Safe Passage Study Cohorts

> **NIH NIH UH3** · AVERA MCKENNAN · 2020 · $80,313

## Abstract

Abstract
Dr. Sania proposes to elucidate relationships between maternal depression and child
developmental outcomes using prospectively collected data on prenatal and postnatal
depression and child development from the PASSECHO study. The parent study is currently
collecting prospective data on maternal psychosocial stressors, child development, child
nutrition and home environment. Maternal data are collected at 4 time points, once prenatally,
and at 1, 4- and 9-years post-pregnancy. Measures of different domains of child development
are collected at multiple ages 1 through 11 years. As a part of the re-entry supplement, we
propose to pursue the following aims and hypotheses:
Aim 1 Depression trajectories: To characterize trajectories of maternal depression based on
timing and severity of symptoms prenatally and up to 4-years post-pregnancy.
Aim 2 Link to child development: To estimate the effects of maternal depression trajectories on
child development at ages between 1 and 4 years. We hypothesize that maternal depression
trajectories will be associated with child development scores and that specific patterns of
chronicity and severity of symptoms will predict poorer development outcomes better than either
pre- or post-pregnancy levels alone.
Aim 3 Risk and Resilience: To test the hypothesis that indicators of physical health and early
childhood environments moderate the effects of depression on child development.

## Key facts

- **NIH application ID:** 10051191
- **Project number:** 3UH3OD023279-05S1
- **Recipient organization:** AVERA MCKENNAN
- **Principal Investigator:** Amy J Elliott
- **Activity code:** UH3 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $80,313
- **Award type:** 3
- **Project period:** 2016-09-21 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10051191

## Citation

> US National Institutes of Health, RePORTER application 10051191, Environmental Influences on Childhood Outcomes in the Northern Plains Safe Passage Study Cohorts (3UH3OD023279-05S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10051191. Licensed CC0.

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