# Extensions of Mendelian Randomization Methodology for Combined Genomic and Methylomic Analysis

> **NIH NIH R01** · VIRGINIA COMMONWEALTH UNIVERSITY · 2020 · $374,370

## Abstract

Project Summary
This project aims to develop and apply novel statistical approaches to address key
causal questions in the of substance use, abuse and dependence. The
development will focus on extending Mendelian Randomization methodology to
new data types that test its key assumptions. These developments include:
estimating and controlling for biases due to non- random mating; analyses of data
from unrelated but genotyped individuals; extension to longitudinal data;
multivariate network models; and multiple-group analyses to test for sex, age and
other group differences. These new methods will be applied to unique longitudinal
phenotype, genotype and methylation data on smokers and non- smokers from the
Netherlands Twin Register, and data from the UK biobank. Precise identification of
causal pathways will enable evidence- based prevention and treatment methods to
be devised and implemented.

## Key facts

- **NIH application ID:** 10052267
- **Project number:** 1R01DA049867-01A1
- **Recipient organization:** VIRGINIA COMMONWEALTH UNIVERSITY
- **Principal Investigator:** MICHAEL CHURTON NEALE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $374,370
- **Award type:** 1
- **Project period:** 2020-07-01 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10052267

## Citation

> US National Institutes of Health, RePORTER application 10052267, Extensions of Mendelian Randomization Methodology for Combined Genomic and Methylomic Analysis (1R01DA049867-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10052267. Licensed CC0.

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