# Epidemiology, impact, and experience of acne in transgender persons

> **NIH NIH K23** · EMORY UNIVERSITY · 2020 · $157,788

## Abstract

PROJECT SUMMARY / ABSTRACT
 The overall objective of this K23 proposal is to support new research training and experience crucial for the
candidate, Howa Yeung, MD MSc, to become an independent, patient-oriented investigator addressing sexual
and gender minority disparities in skin diseases – such as acne in transgender persons. Acne significantly
impairs health-related quality of life and is associated with depression, low self-esteem, and suicidal ideation.
Little is known about the interplay of endogenous and exogenous hormones on acne incidence, severity,
impact, treatment, and experience. Our prior studies noted higher acne prevalence associated with hormone
therapy and identified specific barriers for severe acne treatment in transgender persons. This proposal aims to
examine the epidemiology, impact, and experience of acne in the context of hormone therapy in transgender
persons – a health disparity population with significant knowledge gaps in skin health. The epidemiology of
acne will be examined using data from the existing large-scale, validated, multicenter Study of Transition,
Outcomes and Gender (STRONG). Factors that mediate differences in acne experience, treatment, and
research participation will be newly elicited using mixed methods. Development and pilot testing of a
recruitment protocol and collection of preliminary data on acne outcomes and mental health comorbidity will
help initiate a prospective cohort study of acne in transgender persons receiving hormone therapy. To achieve
these aims, the candidate will require additional training through a combination of formal didactics, practical
research experience, and expert multidisciplinary mentorship. The candidate will build expertise in sexual and
gender minority health and health disparities research, patient-oriented outcomes research in acne, mixed-
methods research techniques, as well as experience in community-engaged research and patient recruitment.
The candidate’s mentored training and research plans will enable him to launch a successful career as an
independent patient-oriented investigator addressing sexual and gender minority disparities in skin diseases –
such as acne in transgender persons. Key results will inform new acne and gender-affirming hormone
treatment paradigms and the design and implementation of future interventions, aimed to reduce the identified
acne disparities, optimize acne clinical outcomes, and to improve patient-centeredness of hormone therapy in
transgender persons.

## Key facts

- **NIH application ID:** 10055481
- **Project number:** 1K23AR075888-01A1
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Howa Yeung
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $157,788
- **Award type:** 1
- **Project period:** 2020-08-20 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10055481

## Citation

> US National Institutes of Health, RePORTER application 10055481, Epidemiology, impact, and experience of acne in transgender persons (1K23AR075888-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10055481. Licensed CC0.

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