# Collaborative Research to Validate Biomarkers of Pediatric ARDS

> **NIH NIH UG1** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $272,203

## Abstract

   
DESCRIPTION (provided by applicant): The NICHD Collaborative Pediatric Critical Care Research Network (CPCCRN, UG1) was established in 2004 to address the following: (1) increased utilization of costly and complex pediatric critical care services and (2) lack of prospective clinical trials in pediatric critical care compared with adult and neonatal populations The primary Aim of this application is to join the CPCCRN as a clinical site, in order to expand our single center prospective observational cohort of pediatric patients with Acute Respiratory Distress Syndrome (ARDS) through enrollment at multiple CPCCRN Sites. ARDS is a common cause of pediatric critical illness (30% of PICU mortalities). We propose to enroll 800 pediatric patients with ARDS and collect clinical data with plasma and genetic biomarkers of coagulation and inflammation. The data obtained will be essential for stratifying prospective clinical research
trials and will provide insight into basic molecular and cellular disease mechanisms necessary for designing new treatments. UCSF Medical Center and Benioff Children's Hospital, the Department of Pediatrics and Division of Pediatric Critical Care Medicine have a long history of participation in ground breaking multicenter clinical research, as well as cutting edge individual investigator driven basic, translational and clinical research. This tradition, coupled with deep institutional resources for biomedical research, makes our center ideally positioned to contribute novel proposals to the consortium and participate fully in network-sponsored studies

## Key facts

- **NIH application ID:** 10056715
- **Project number:** 3UG1HD083166-05S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Patrick Sean McQuillen
- **Activity code:** UG1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $272,203
- **Award type:** 3
- **Project period:** 2014-12-24 → 2020-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10056715

## Citation

> US National Institutes of Health, RePORTER application 10056715, Collaborative Research to Validate Biomarkers of Pediatric ARDS (3UG1HD083166-05S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10056715. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*