# The Military HIV Research Program (MHRP) Clinical Trial Unit

> **NIH NIH UM1** · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2021 · $2,272,671

## Abstract

Project Summary
The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) and the
Walter Reed Army Institute of Research (WRAIR) propose to extend and diversify the existing
U.S. Military HIV Research Program (MHRP) Clinical Trials Unit (CTU). The proposed MHRP
CTU will leverage its existing network structure, which has been developed with the support of
the United States Army, the Division of AIDS (DAIDS) and others, to extend the current DAIDS-
funded CTU activity. The current CTU configuration supports the AIDS Clinical Trials Group at
two sites and the HIV/AIDS Vaccine Trial Network (HVTN) at two other sites. In this new
proposal, we seek to expand to a total of 8 sites all of which will support both the HVTN and the
HIV/AIDS Prevention Trials Network (HPTN) and increase ACTG affiliations from 2 to 4 of these
sites. To provide stronger support to the new network goals of TB treatment and prevention,
MHRP has formed a strategic partnership with the IAVI to form a potent collaboration supporting
both the science and development of novel interventions for both HIV and TB prevention and
treatment. The MHRP CTU will comprise a core management group located at WRAIR in
Maryland, United States and eight international Clinical Research Sites (CRS) located in Africa
and Asia. These sites will implement clinical protocols from phase I safety trials to phase III
efficacy trials and are located in areas with substantial HIV burden and populations suitable to
participate in planned prevention and therapeutic clinical trials. MHRP’s experience and
innovation in HIV vaccine research and demonstrated capability to address emerging priorities
of HIV cure research will contribute scientifically to the DAIDS vaccine and therapeutics
leadership networks. IAVI will contribute both HIV prevention and TB vaccine scientific
leadership. The expanded MHRP CTU will bring DAIDS, and the networks MHRP is proposing
affiliation with, valuable clinical research capacity with Department of Defense and IAVI
supported staff. Specific aims of the proposal include:
 1. Provide scientific leadership, novel products and innovative approaches.
 2. Provide clinical trial execution of the HIV Vaccine Clinical Trials Network and the HIV
 Prevention Clinical Trials Network scientific agenda.
 3. Provide clinical trial execution of the HIV/AIDS Adult Therapeutics Clinical Trials Network
 scientific agenda.

## Key facts

- **NIH application ID:** 10057645
- **Project number:** 2UM1AI108568-08
- **Recipient organization:** HENRY M. JACKSON FDN FOR THE ADV MIL/MED
- **Principal Investigator:** Julie A. Ake
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $2,272,671
- **Award type:** 2
- **Project period:** 2013-12-10 → 2027-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10057645

## Citation

> US National Institutes of Health, RePORTER application 10057645, The Military HIV Research Program (MHRP) Clinical Trial Unit (2UM1AI108568-08). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10057645. Licensed CC0.

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