# Botswana-Harvard T.H. Chan School of Public Health AIDS Initiative Partnership CTU

> **NIH NIH UM1** · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2021 · $1,941,572

## Abstract

Summary/Abstract
This is an application to renew a Clinical Trials Unit (CTU) in Botswana that will conduct research related
to adult and pediatric HIV therapeutic strategies; interventions to address HIV-associated
infections/conditions in pediatric and maternal populations; treatment and prevention of tuberculosis in
adults (including pregnant women) and children with and without HIV; and integrated HIV prevention
strategies in pediatric and adult populations.
These activities will occur through participation in three research networks: 1) the HIV/AIDS Adult
Therapeutics Clinical Trials Network; 2) HIV/AIDS Maternal, Adolescent and Pediatric Therapeutics
Clinical Trials Network, and 3) the HIV Prevention Clinical Trials Network. We will perform multi-center
studies at our two established CRSs: one in Gaborone (all 3 networks), the capital city of Botswana, and
the other in Molepolole (Maternal, Adolescent and Pediatric Therapeutics network only), the largest
village in Botswana. We will thus work with both urban and village populations of all ages and of both
sexes.
The primary objective of this proposal is therefore to renew a CTU in Botswana that will participate in and
contribute to the following high-impact areas of research:
 Novel and durable treatments for HIV in adults (including pregnant women) and children
 Strategies to induce ART-free HIV remission (or eradication) in adults and children
 Treatment and prevention of HIV-related complications and co-infections in adults and children
 New treatments / modalities and prevention approaches for tuberculosis in adults and children
 HIV prevention strategies, including pre-exposure prophylaxis and integrated prevention approaches
Within each of these research areas, this CTU will contribute significantly to:
 Enrolling participants into and conducting high-quality clinical research studies,
 Participating in network activities, including protocol teams and scientific / resource committees, and
 Conceiving and proposing new, relevant, high-impact studies in priority areas

## Key facts

- **NIH application ID:** 10057775
- **Project number:** 2UM1AI069456-15
- **Recipient organization:** HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH
- **Principal Investigator:** SHAHIN LOCKMAN
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,941,572
- **Award type:** 2
- **Project period:** 2007-02-01 → 2027-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10057775

## Citation

> US National Institutes of Health, RePORTER application 10057775, Botswana-Harvard T.H. Chan School of Public Health AIDS Initiative Partnership CTU (2UM1AI069456-15). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10057775. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*