# Mouse Core

> **NIH NIH P01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2020 · $147,113

## Abstract

The overall goal of this Core laboratory is to provide the infrastructure, materials, animals, technical expertise
and support that will facilitate the use of humanized immunodeficient mice in studies that examine HIV
reservoirs in vivo. Recent advances have enabled the use of mice that lack their own immune system mice to
be implanted with human tissue. Human tissue capable of developing into human immune cells is placed in
the mice where it undergoes development into multiple types of human immune cells. The human tissue used
in these studies is capable of a high degree of manipulation and experimentation in the mouse and the human
cells, versus the mouse cells, are further susceptible to infection with HIV. This provides a powerful model to
examine human blood cell development, to study the effects of HIV infection on human cells, and examine
ways to purge HIV from immune cells. The generation of these humanized mice is a highly specialized
procedure, due to the requirement for immunodeficient mouse strains, human hematopoietic tissue, infectious
material, specialized facilities, and the necessary skill and knowledge to perform experiments in this system.
This new core would represent a unique and valuable resource for this program, as the director of the Core
has greater than 24 years of experience with humanized mouse models and the staff of the core have helped
pioneer various novel techniques and findings in these models. In order for us to accurately assess and
compare our results, standardization of the mouse model becomes absolutely critical. Thus, it is essential for
this program, in order to draw the proper conclusions, that the studies involving humanized mice be
standardized between laboratories. The central purpose of this core is to provide the specialized services and
resources needed by all 3 projects in this program in the standardized fashion necessary to generate
consistent and reliable data.

## Key facts

- **NIH application ID:** 10057932
- **Project number:** 5P01AI131294-04
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** SCOTT G KITCHEN
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $147,113
- **Award type:** 5
- **Project period:** 2017-08-10 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10057932

## Citation

> US National Institutes of Health, RePORTER application 10057932, Mouse Core (5P01AI131294-04). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10057932. Licensed CC0.

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