# Multivariate methods for identifying multitask/multimodal brain imaging biomarkers

> **NIH NIH R01** · GEORGIA STATE UNIVERSITY · 2020 · $542,808

## Abstract

Project Summary/Abstract
 The brain is extremely complex as we know, and involves a complicated interplay between functional infor-
mation interacting with a structural (but not static) substrate. Brain imaging technology provides a way to sample
various aspects of the brain albeit incompletely, providing a rich set of multitask and multimodal information. The
field has advanced significantly in its approach to multimodal data, as there are more studies correlating, e.g.
functional and structural measures. However, the vast majority of studies still ignore the joint information among
two or more modalities or tasks. Such information is critical to consider as each brain imaging modality reports
on a different aspect of the brain (e.g. gray matter integrity, blood flow changes, white matter integrity). The field
is still striving to understand how to diagnose and treat complex mental illness, such as schizophrenia, bipolar
disorder, depression, and others, and ignoring the joint information among tasks and modalities misses a critical,
but available, part of the puzzle. Combining multimodal imaging data is not easy since, among other reasons,
the combination of multiple data sets consisting of thousands of voxels or timepoints yields a very high dimen-
sional problem, requiring appropriate data reduction strategies. In the previous phase of the project we devel-
oped advanced approaches to capture high-dimensional relationships among 2 or more modalities. Our work
continues to strongly support the benefits of multimodal data fusion to both provide a more complete picture of
brain function and structure, but also to improve our ability to study and predict the impact of complex mental
illness. In this new phase of the project, we will focus on methods that can fill some existing gaps, such as the
ability to bridge spatial/temporal as well as structural/functional connectivity scales. We also propose a novel
framework to integrate unimodal and multimodal features called chromatic fusion, which searches for combina-
tions of multimodal `notes' which occupy a unique position in a latent (or dictionary) space. The proposed meth-
ods will be validated using simulations, hybrid-data, and large N normative imaging data. Our proposed approach
will be thoroughly tested using this large data set which includes multiple illnesses that have overlapping symp-
toms and which can sometimes be misdiagnosed and treated with the wrong medications for months or years
(schizophrenia, bipolar disorder, and unipolar depression). We will provide open source tools and release data
throughout the duration of the project via GitHub and the NITRIC repository, hence enabling other investigators
to compare their own methods with our own as well as to apply them to a large variety of brain disorders.
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## Key facts

- **NIH application ID:** 10058554
- **Project number:** 2R01EB006841-14
- **Recipient organization:** GEORGIA STATE UNIVERSITY
- **Principal Investigator:** VINCE D CALHOUN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $542,808
- **Award type:** 2
- **Project period:** 2007-04-01 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10058554

## Citation

> US National Institutes of Health, RePORTER application 10058554, Multivariate methods for identifying multitask/multimodal brain imaging biomarkers (2R01EB006841-14). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10058554. Licensed CC0.

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