# Understanding the effects of adjuvant endocrine therapy on thermoregulation

> **NIH NIH R21** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2020 · $401,115

## Abstract

PROJECT SUMMARY
Tamoxifen is an estrogen-like drug that is used to treat breast cancer patients, breast cancer survivors, and
patients with a family history of breast cancer. As a treatment, tamoxifen is extremely effective at decreasing
the changes of getting cancer and increasing patient survival. The goal of our research is to understand
how tamoxifen may affect other estrogen-sensitive tissues, specifically the hypothalamus. We hypothesize
that tamoxifen alters estrogen receptor signaling in the hypothalamus and that this dysregulation underlies
the generation of hot flashes in patients undergoing tamoxifen therapy. We will use cutting-edge molecular
tools to define the tamoxifen-sensitive cell types within the hypothalamus and genetically engineered mice
to identify the cell types and receptors that mediate the effects of tamoxifen on temperature control. This
information will help us better understand how tamoxifen therapy impacts the brain. Ultimately, this
information could be used to design treatments or adjuvants that provide relief from the side effects of
tamoxifen and improve quality of life for breast cancer patients and survivors.

## Key facts

- **NIH application ID:** 10058783
- **Project number:** 1R21CA249338-01A1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Stephanie Correa
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $401,115
- **Award type:** 1
- **Project period:** 2020-07-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10058783

## Citation

> US National Institutes of Health, RePORTER application 10058783, Understanding the effects of adjuvant endocrine therapy on thermoregulation (1R21CA249338-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10058783. Licensed CC0.

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