# GLUCOSE AND AMINO ACID CATABOLISM IN PLASMA CELL BIOLOGY

> **NIH NIH R01** · UNIVERSITY OF ARIZONA · 2021 · $460,132

## Abstract

The usage of metabolic pathways is tailored to meet the specific functions and demands of a given cell type. Of particular interest is how metabolism supports the survival and antibody secretion of long-lived cells, the primary cell type that is responsible for humoral immunity. Using plasma cells as a model system, we will define how glucose and amino acid uptake supports long-term persistence of these antibody-secreting cells. In preliminary data, we demonstrate that long-lived plasma cells import far more glucose than do their short-lived counterparts. Glucose is primarily used to glycosylate antibodies, but a portion of this glucose can be used for glycolysis, and the resultant pyruvate imported into the mitochondria. Short-lived plasma cells do not have this capacity. We propose to define the metabolic fates of pyruvate and explain why this pathway is important in long-lived plasma cells. We also propose to define how long-lived plasma cells balance enhanced antibody production with nutrient uptake and ER stress. Finally, we seek to define the physiological signals that promote plasma cell metabolic programs following vaccination. The application heavily emphasizes new genetic and in vivo approaches to define, report, and functionally test critical metabolic pathways in a cell type critical for humoral immunity.

## Key facts

- **NIH application ID:** 10059162
- **Project number:** 5R01AI129945-04
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** Deepta Bhattacharya
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $460,132
- **Award type:** 5
- **Project period:** 2017-12-13 → 2022-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10059162

## Citation

> US National Institutes of Health, RePORTER application 10059162, GLUCOSE AND AMINO ACID CATABOLISM IN PLASMA CELL BIOLOGY (5R01AI129945-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10059162. Licensed CC0.

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