# The Role of Stem Cells and the Microenvironment in Gastrointestinal Cancers

> **NIH NIH R35** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2021 · $871,044

## Abstract

Summary/Abstract
This project seeks to investigate the role of nerves and other stromal cells in the development of
digestive cancers, including stomach, esophageal, colon and pancreas. The project builds on
previous work that suggests that these elements can regulate stem cells, and that inhibiting
stromal cells in the microenvironment, it may be possible to inhibit the development of tumors.

## Key facts

- **NIH application ID:** 10059178
- **Project number:** 5R35CA210088-05
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Timothy Cragin Wang
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $871,044
- **Award type:** 5
- **Project period:** 2016-12-07 → 2023-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10059178

## Citation

> US National Institutes of Health, RePORTER application 10059178, The Role of Stem Cells and the Microenvironment in Gastrointestinal Cancers (5R35CA210088-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10059178. Licensed CC0.

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