PROJECT SUMMARY OF THE ADMINISTRATIVE CORE Our thriving Center of Excellence for Natural Product Drug Interaction Research (NaPDI Center) has achieved tremendous success in establishing rigorous and definitive approaches for the design and conduct of natural product (NP)-drug interaction (NPDI) studies and advancing our understanding of pharmacokinetic NPDIs precipitated by four carefully selected high priority NPs: green tea, goldenseal, cannabis, and kratom. The success of the NaPDI Center reflects multiple inter-institutional and intra-institutional collaborations that worked effectively and efficiently with logistical, fiscal, and intellectual support provided by the Administrative Core. Roles and responsibilities of the Administrative Core are integrated into all NaPDI Center activities, at both the programmatic and project levels, ensuring that prescribed project milestones are met and within budget. Accomplishments of the Administrative Core derive from a lean leadership structure and regular, effective communication between Center investigators. As detailed in this renewal application, we propose three SPECIFIC AIMS that represent a continuation of existing Core functions with multiple innovations. AIM 1: the Administrative Core will coordinate project activities of the investigators composing the three scientific Cores (Pharmacology, Analytical, and Informatics) and their associated academic institutions, ensuring maximal scientific productivity and fiscal cohesion. The Administrative Core will partner with NCCIH to establish a Steering Committee that 1) oversees the NaPDI Center program, 2) monitors progress of the Interaction Projects and expansion of the data repository and public portal, and 3) recommends changes in scientific direction when warranted. In addition, the Administrative Core will ensure effective communication between Center investigators and the External Advisory Panel by providing regular updates of project progress and tapping the Panel’s wealth of expertise in relevant disciplines to inform strategic directions of the Center and help address specific project challenges. AIM 2: the Administrative Core will work with the Informatics Core to develop and implement innovative metrics to evaluate program success, completion of annual milestones, and impact of specific project outcomes on the scientific field and public health and safety. AIM 3: the Administrative Core will provide leadership for the broad dissemination of best practice methodologies and recommended approaches developed by the Center for the optimal conduct of human mechanistic in vitro and clinical NPDI studies. These activities will include innovative approaches to broaden outreach to national and international scientific communities. Our time-tested administrative team has developed a highly effective operational paradigm that will ensure continued productivity of the Center and translation of Center-generated data to improve public health.