# MRI Assessment of Tumor Perfusion, Permeability and Cellularity

> **NIH NIH R01** · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · 2021 · $399,483

## Abstract

The long-term goal of this project is to improve brain cancer patient care by developing and validating
advanced dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) methods for tumor
characterization and therapeutic response assessment. Improving the biophysical characterization of brain
tumors remains a highly relevant clinical objective. Currently, Contrast-Enhanced MRI (CE-MRI) is the primary
means to detect primary and recurrent tumors and assess therapeutic response for essentially all brain tumor
patients. Yet despite widespread use, CE-MRI accuracy remains limited, as it is incapable of delineating
between tumor types, is confounded by treatment effects and can require months to discern true therapeutic
response. We believe that advanced and clinically optimized DSC-MRI techniques can overcome these
limitations and could impact radiographic diagnosis, response assessment and image-guided biopsies. During
the first period of support of this grant we developed and validated, in pre-clinical animal models, novel DSC-
MRI techniques for quantitative and simultaneous imaging of brain tumor hemodynamics, vascular integrity
and cytoarchitecture. Given the demonstrated validity of these techniques in pre-clinical studies we now seek
to optimize and validate their utility in brain tumor patients. Our first Aim is to develop and optimize a clinically
practical, simultaneous spiral-based spin and gradient echo (SAGE) DSC-MRI strategy for mapping total and
microvascular hemodynamics, vessel size, vessel architecture, vascular permeability and cytoarchitecture.
Such a sequence overcomes many of the obstacles that reduce the quality of current DSC-MRI scans,
requires lower doses of Gadolinium based contrast agents, enables more reliable perfusion measures and
improves registration accuracy between DSC-MRI data and conventional images used for surgical planning.
We next aim to establish threshold values for SAGE based metrics that accurately differentiate high-grade
glioma recurrence from post treatment radiation effect and validate by direct correlation to image-guided tissue
histopathology. This would enable clinicians to make earlier treatment decisions and initiate second-line
therapies sooner. Our final aim is to validate the sensitivity of SAGE-based parameters to histologic tumor
content both within enhancing and non-enhancing tissue. We will determine whether SAGE based metrics,
individually or combined, enable the identification of tumor rich biopsy sampling sites, thereby providing a
validated biomarker-based image guided biopsy approach that could improve histologic and genetic profiling.
SAGE-based measures of tumor perfusion, permeability and cellularity would help overcome many of the
limitations of CE-MRI as they are more likely to improve tumor characterization, localization and offer early and
more specific indicators of treatment response.

## Key facts

- **NIH application ID:** 10062866
- **Project number:** 5R01CA158079-11
- **Recipient organization:** ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER
- **Principal Investigator:** Christopher Chad Quarles
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $399,483
- **Award type:** 5
- **Project period:** 2011-09-16 → 2022-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10062866

## Citation

> US National Institutes of Health, RePORTER application 10062866, MRI Assessment of Tumor Perfusion, Permeability and Cellularity (5R01CA158079-11). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10062866. Licensed CC0.

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