# FASEB's "The Steroid Hormones and Receptors in Health and Disease Conference - Jointly hosted by FASEB and the International Committee on Rapid Responses to Steroid Hormones (RRSH)"

> **NIH NIH R13** · FEDERATION OF AMER SOC FOR EXPER BIOLOGY · 2020 · $17,500

## Abstract

PROJECT SUMMARY/ABSTRACT
Historically, research in the field of steroid hormone signaling has been primarily focused on the transcriptional
effects mediated by steroid hormone receptors (SHRs) acting within the nuclei of cells. It is now recognized that
the same nuclear SHRs that trigger changes in cellular physiology through the regulation of gene expression
can be post-translationally modified and subsequently localized to the cytosol and/or surface membrane to
mobilize a variety of intracellular signaling pathways. In addition, new SHRs that function solely outside the
nucleus have been identified. These extranuclear effects of SHRs regulate a myriad of biological processes
relevant to human health and disease. SHRs rarely act in isolation, but rather synchronize cytoplasmic and
nuclear signaling pathways via complex networks of interacting molecules that serve to optimize physiological
endocrine functions. Conversely, dysfunctional endocrine systems have a profound impact on health and can
lead to various disease states. Not surprisingly, the field has rapidly expanded, such that hundreds of scientific
papers are published on the topic each year. Thus, to better understand the myriad of SHR-regulated signaling
pathways and their physiological and pathological impact, it is essential to bring together researchers across the
field of endocrinology to disseminate new findings, generate novel hypotheses, find consensus on current issues
and best approaches, and uncover new and/or unifying themes. To do so, the members of the FASEB scientific
research group “Rapid Signaling and Genomic Steroid Hormone Actions in Health & Disease" will come together
for the first time to with the participants of the international “Rapid Responses to Steroid Hormones” (RRSH) to
explore emerging data regarding the integration of nuclear and extranuclear SHR function. The title of this joint
conference is “The Rapid Signaling and Genomic Steroid Hormone Actions in Health and Disease.” The major
aims of this conference are to (1) highlight recent research discoveries in the context of integrated SHR actions
relevant to health and disease (2) promote the career development of emerging scientists and trainees to ensure
the continued vibrancy of the field and (3) further existing research interactions to foster new partnerships that
will advance knowledge and foster innovation.

## Key facts

- **NIH application ID:** 10063235
- **Project number:** 1R13DK126171-01
- **Recipient organization:** FEDERATION OF AMER SOC FOR EXPER BIOLOGY
- **Principal Investigator:** Daniel Edward Frigo
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $17,500
- **Award type:** 1
- **Project period:** 2020-07-21 → 2021-07-20

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10063235

## Citation

> US National Institutes of Health, RePORTER application 10063235, FASEB's "The Steroid Hormones and Receptors in Health and Disease Conference - Jointly hosted by FASEB and the International Committee on Rapid Responses to Steroid Hormones (RRSH)" (1R13DK126171-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10063235. Licensed CC0.

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