# UC Irvine AD Translational Center for Disease Model Resources-Supplement to Purchase MESO QUICKPLEX SQ 120

> **NIH NIH U54** · UNIVERSITY OF CALIFORNIA-IRVINE · 2020 · $58,723

## Abstract

Project Summary/Abstract
A key goal of the UCI MODEl-AD Disease Model Development and Phenotyping Project (DMDPP) is
to generate and phenotype new models of Alzheimer's disease (AD) that better recapitulate late
onset AD (LOAD). The LOAD models will be generated on a platform of humanized Ab and tau, two
hallmark pathological proteins found in AD. Once humanized, we will then introduce AD-risk
associated polymorphisms in genes to test their ability to drive characteristics of LOAD. The ultimate
goal is the production and characterization of a mouse that can be used to explore the key drivers of
AD pathology in the aging process, both genetic and environmental. Standard measures of Aβ40 and
Aβ42 and total and phospho-tau levels, inflammatory markers will be performed for each genotype and
age. In addition, neurofilament light, a newly investigated translatable biomarker, can be quantified in
these animals. This involves, at a minimum, analysis of 1000 samples of plasma, hippocampus and
cortex for every mouse model in the next 3 years. The Meso Quickplex SQ120 instrument provides
several advances compared to pre-existing enzyme-linked immunosorbent assay (ELISA) system, as
it enables simultaneous tests on a single sample and it is a high-performance
electrochemilunescence immunoassay. Furthermore, the same system is being used in the other
MODEL-AD centers to obtain these endpoints in their phenotyping protocols, and thus it is important
for UCI to harmonize with the other consortium members.

## Key facts

- **NIH application ID:** 10063351
- **Project number:** 3U54AG054349-03S7
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** FRANK M LAFERLA
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $58,723
- **Award type:** 3
- **Project period:** 2017-09-15 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10063351

## Citation

> US National Institutes of Health, RePORTER application 10063351, UC Irvine AD Translational Center for Disease Model Resources-Supplement to Purchase MESO QUICKPLEX SQ 120 (3U54AG054349-03S7). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/10063351. Licensed CC0.

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