# Multi-component Intervention for Diabetes in Adults with Serious Mental Illness (MIDAS)

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2020 · $189,744

## Abstract

Project Summary/Abstract
Serious mental illnesses (SMI), including schizophrenia, bipolar disorder, and schizoaffective disorder, are
associated with increased medical comorbidity and premature mortality from diabetes and cardiovascular
disease. Unhealthy lifestyles, including energy-dense (obesogenic) diet, sedentary behavior, and cigarette
smoking are important risk factors for diabetes and accelerated biological aging. All of these risk factors are
potentially modifiable. There is considerable literature documenting the effectiveness of strategies to prevent
and manage diabetes in the general population; yet, these interventions are rarely offered to people with SMI.
Residential Care Facilities (RCFs), called Board-and-Care Homes in California, are a common housing
modality for patients with SMI; they provide a venue that can maximize efficiency and sustainability of a
lifestyle intervention. The goals of the proposed four-year study are to tailor a multi-component intervention to
this high-risk group. The study will be a hybrid effectiveness-implementation (Hybrid Type 1) trial of a Multi-
component Intervention for Diabetes risk reduction in Adults with SMI (MIDAS) in licensed RCFs in San Diego
county. As a Hybrid Type 1 study, the primary emphasis will be on determining the effectiveness of the
intervention to achieve desired health outcomes while also systematically collecting data on its implementation
within RCFs that will inform implementation strategy refinement. Main components of MIDAS include: (1)
Education about diabetes and lifestyle, (2) Dietary intervention at the facility and resident level, (3) Increased
physical activity, and (4) Smoking cessation / reduction. We will employ a modified cluster-randomized stepped
wedge and adaptive trial design involving 210 residents with SMI and 120 staff members from 12 RCFs. The
RCFs will be divided randomly into four cohorts of three RCFs each. Each cohort will be tested over a 15-
month period that includes three phases: a three-month initial control phase (no intervention, from baseline
month 0 to end of month 3), a six-month intervention phase (months 4 through 9), and a six-month follow-up
phase (no intervention, months 10 through 15). All the study participants will be assessed quarterly during the
15-month period. Our investigators will train RCF staff (especially the Activity Director and cook) to increase
physical activity and reduce smoking, and to implement healthful dietary modifications among the residents,
using evidence-based interventions. During the intervention phase, the RCF Activity Director will conduct
twice-weekly manualized group sessions on education about diabetes, nutrition, exercise, and smoking
cessation/reduction, to deliver a multi-component group intervention. We will also explore if there are
improvements in blood-based research biomarkers of insulin resistance and inflammation in the RCF residents
with SMI. This project is responsive to RFA-MH-17-608, and ...

## Key facts

- **NIH application ID:** 10063409
- **Project number:** 3R01MH115127-03S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** DILIP V. JESTE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $189,744
- **Award type:** 3
- **Project period:** 2018-09-01 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10063409

## Citation

> US National Institutes of Health, RePORTER application 10063409, Multi-component Intervention for Diabetes in Adults with Serious Mental Illness (MIDAS) (3R01MH115127-03S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10063409. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*