# Sex Differences in Methylome Alterations and Mutational Burden in Early Stage Melanoma

> **NIH NIH P01** · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2020 · $95,969

## Abstract

PROJECT SUMMARY/ABSTRACT
The proposed project aims to address a current gap in our understanding of the role of biological sex in overall
survival among melanoma AJCC TNM stages IIA/IIB/IIC/IIIA/IIIB/IIIC/IIID. We will evaluate methylome
alterations and mutational burden in the primary tumors of 1000 melanoma patients with the goal of 1)
identifying underlying mechanisms for observed disparities in melanoma overall survival between men and
women, and 2) identifying subclasses of methylome alterations and mutational signatures associated with sex
and survival.

## Key facts

- **NIH application ID:** 10063456
- **Project number:** 3P01CA206980-04S1
- **Recipient organization:** UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
- **Principal Investigator:** MARIANNE BERWICK
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $95,969
- **Award type:** 3
- **Project period:** 2017-06-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10063456

## Citation

> US National Institutes of Health, RePORTER application 10063456, Sex Differences in Methylome Alterations and Mutational Burden in Early Stage Melanoma (3P01CA206980-04S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10063456. Licensed CC0.

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