# Animal Production Core

> **NIH NIH P60** · INDIANA UNIVERSITY INDIANAPOLIS · 2021 · $299,959

## Abstract

Project Summary: Animal Production Core
Alcohol and other substance abuse continue to be enormous public health issues with total costs in the US
approaching a half billion dollars a year. Although there are major attempts at prevention, a better
understanding of the genetic and environmental factors that increase the risk of alcohol use disorders, the
neural circuits that underlie this risk, and the ability to regulate these circuits therapeutically are all still critically
needed. In addressing this critical need, this Animal Production Core will continue to provide the P/NP and
HAD/LAD rats, as well as the HAP/LAP and cHAP mice that have been selectively bred for a high vs low
alcohol preference, to investigators in the Indiana Alcohol Research Center (IARC) or on the Indiana
University–Purdue University at Indianapolis (IUPUI) campus. This Core is the outgrowth of over 30 years of
experience with selective breeding, maintenance of breeding colonies, and solving problems arising with the
logistics and nature of running an operation of this magnitude. We are therefore uniquely qualified in the
coming funding period to continue to provide these animals to alcoholism and addiction researchers, to
coordinate the use of the animals to avoid scientific overlap, and to manage issues that could affect their
phenotype and associated behaviors. Addiction has become a disease of co-abuse, with the majority of
individuals dependent on alcohol often being dependent on other licit or illicit substances as well. Given this,
there are likely common environmental and genetic factors that result in a broad predisposition to the abuse of
many substances, as well as alcohol specifically. The Animal Production Core will continue to characterize
these lines (high vs low preference) as animal models of addiction, and promote their use in examining the
genetic and neurobiological substrates of substance use, abuse and dependence.

## Key facts

- **NIH application ID:** 10064086
- **Project number:** 5P60AA007611-34
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** RICHARD LOWELL BELL
- **Activity code:** P60 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $299,959
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10064086

## Citation

> US National Institutes of Health, RePORTER application 10064086, Animal Production Core (5P60AA007611-34). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10064086. Licensed CC0.

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