# Indoor Air Pollution and Outcomes in Cystic Fibrosis

> **NIH NIH F32** · JOHNS HOPKINS UNIVERSITY · 2020 · $87,430

## Abstract

PROJECT SUMMARY
Cystic Fibrosis (CF) is a lethal autosomal recessive disease affecting nearly 80,000 people worldwide. Despite
advances in therapy, CF remains a progressive lung disease that leads to decline in lung function and frequent
pulmonary exacerbations.
Higher levels of outdoor air pollution, including particulate matter (PM) with a diameter of 10µm or less (PMR10R)
and 2.5µm or less (PMR2.5R), nitrogen dioxide (NOR2R), and ozone, have been shown to lead to worse CF
outcomes such as decline in lung function and increased pulmonary exacerbations. Many studies have shown
that higher levels of indoor air pollution increase morbidity in obstructive lung diseases such as asthma and
COPD. To our knowledge, this has not been studied in individuals with CF, also an obstructive lung disease.
In this proposal we aim to study how indoor air pollution affects individuals with CF. We hypothesize that
higher levels of indoor air pollution are associated with worse CF outcomes, such as increased respiratory
symptoms and decline in lung function.
To explore our hypothesis, we will conduct a sub-analysis from data collected in the US CF Twin and Sibling
Study, which includes data on exposure to sources of indoor air pollution and clinical outcomes on over 2000
CF individuals from 2000-13. Next, we will distribute a survey to our local CF cohort to gather more detailed
home exposure data and follow respiratory symptoms and lung function over time. Finally, we will conduct a
pilot study to measure daily PMR2.5R and weekly NOR2R and nicotineR Rlevels inside the homes of 20 patients with CF
for two one-week periods, separated by season, and ask patients to answer a daily respiratory symptoms
questionnaire, complete daily activity diaries, and perform daily home spirometry. We will then determine if
daily variations in PMR2.5 Rand weekly levels of NOR2R and nicotine are associated with daily variation in respiratory
symptoms and lung function.
The research carried out in this proposal is of public health significance and will provide new information on
how indoor air pollution affects CF. The results of this study may impact the entire CF community and will
serve as a catalyst for a future, multi-center and interventional study which will be the basis for my K23
application.

## Key facts

- **NIH application ID:** 10065102
- **Project number:** 1F32HL149262-01A1
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Sara Weller Carson
- **Activity code:** F32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $87,430
- **Award type:** 1
- **Project period:** 2020-07-02 → 2021-07-01

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10065102

## Citation

> US National Institutes of Health, RePORTER application 10065102, Indoor Air Pollution and Outcomes in Cystic Fibrosis (1F32HL149262-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10065102. Licensed CC0.

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